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ML 239

Cat. No. 4829 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Breast cancer stem cell inhibitor
化学名： 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
文献 (5)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 239

ML 239 is a breast cancer stem cell inhibitor (IC50 = 1.16 μM). Exhibits 24-fold selectivity for breast cancer stem cells over normal mammary epithelial cells. Also cytotoxic towards MDA-MB-231 breast cancer cells in vitro.

技术数据 for ML 239

分子量 346.6
公式 C13H10Cl3N3O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1378872-36-6
PubChem ID 90488975
InChI Key WOCCOXNODBCCGK-UHFFFAOYSA-N
Smiles ClC1=C(OCC(N/N=C/C2=CC=CN2)=O)C(Cl)=CC(Cl)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 239

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.66 100
ethanol 17.33 50

制备储备液 for ML 239

以下数据基于产品分子量 346.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.43 mL 28.85 mL
5 mM 0.58 mL 2.89 mL 5.77 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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产品说明书 for ML 239

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ML 239

参考文献是支持产品生物活性的出版物。

Carmody et al (2012) Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. J.Biol.Chem. 17 1204 PMID: 22941295

Germain et al (2012) Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg.Med.Chem.Lett. 22 3571 PMID: 22503247

If you know of a relevant reference for ML 239, please let us know.

按标靶查看相关产品

关键词: ML 239, ML 239 supplier, ML239, breast, cancer, stem, cells, inhibitors, inhibits, Cancer, Stem, Cells, 4829, Tocris Bioscience

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ML 239 的评论

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Action of ML 239 on CSC cell lines.
By Anonymous on 10/12/2019
种属： Human

ML 239 was tested to find whether it was toxic to two CSC-like lines.Gene expression studies showed altered gene expression in the NF kappa B pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML 239.

Dissolved in DMSO

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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