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Submit ReviewML 289
Discontinued Product
4976 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
说明： Selective negative allosteric modulator of mGlu3 receptors
化学名： [(3R)-3-(Hydroxymethyl)-1-pipridinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]methanone
纯度： ≥98% (HPLC)
生物活性 for ML 289
ML 289 is a selective negative allosteric modulator at mGlu3 receptors (IC50 = 660 nM). Exhibits 15-fold selectivity for mGlu3 over mGlu2. Centrally penetrant.
技术数据 for ML 289
| 分子量 | 349.42 |
| 公式 | C22H23NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1382481-79-9 |
| PubChem ID | 56587994 |
| InChI Key | VSLWUPHHCFQTDB-LJQANCHMSA-N |
| Smiles | O=C(N3CCC[C@@H](CO)C3)C(C=C2)=CC=C2C#CC1=CC=C(OC)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ML 289
参考文献 for ML 289
参考文献是支持产品生物活性的出版物。
Sheffler et al (2012) Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg.Med.Chem.Lett. 22 3921 PMID: 22607673
关键词: ML 289, ML 289 supplier, ML289, selective, allosteric, modulators, mglu3, mglu_3, metabotropic, glutamate, receptors, NAMs, group, II, 2, Glutamate, (Metabotropic), Group, Receptors, 4976, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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