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ML 299

Cat. No. 4894 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent inhibitor of PLD1 and PLD2; CNS penetrant
化学名： 4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 299

ML 299 is a selective allosteric modulator and potent inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML 299 decreases invasive migration in glioblastoma cells and increases caspase 3/7 activity in serum-free conditions. ML 299 is non-cytotoxic, active in vivo and CNS penetrant.

技术数据 for ML 299

分子量 489.39
公式 C23H26BrFN4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1426916-00-8
PubChem ID 56593054
InChI Key RFKXAYJUFUZBMA-INIZCTEOSA-N
Smiles O=C(N[C@@H](C)CN1CCC2(C(NCN2C3=CC(F)=CC=C3)=O)CC1)C4=CC=C(Br)C=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 299

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 48.94 100

制备储备液 for ML 299

以下数据基于产品分子量 489.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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参考文献 for ML 299

参考文献是支持产品生物活性的出版物。

O'Reilly et al (2013) Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J.Med.Chem. 56 2695 PMID: 23445448

If you know of a relevant reference for ML 299, please let us know.

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关键词: ML 299, ML 299 supplier, ML299, potent, inhibitor, inhibitors, inhibition, phospholipaseD, phospholipaseD2, phospholipases, allosteric, modulator, PLD1, PLD2, selective, Phospholipases, 4894, Tocris Bioscience

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