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Submit ReviewML 354
说明： Selective PAR4 antagonist
化学名： 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol
纯度： ≥98% (HPLC)
生物活性 for ML 354
ML 354 is a selective PAR4 antagonist (IC50 = 140 nM). Exhibits 70-fold selectivity for PAR4 over PAR1.
技术数据 for ML 354
| 分子量 | 282.29 |
| 公式 | C16H14N2O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 89159-60-4 |
| PubChem ID | 752812 |
| InChI Key | GNJUKVGDCUKDLF-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=C([N+]([O-])=O)C=C1C(C3=CC=CC=C3)=C2CO |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ML 354
参考文献 for ML 354
参考文献是支持产品生物活性的出版物。
Wen et al (2014) Substituted indoles as selective protease activated receptor 4 (PAR4) antagonists: Discovery and SAR of ML354. Bioorg.Med.Chem.Lett. 24 4708 PMID: 25176330
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关键词: ML 354, ML 354 supplier, ML354, SID161004646, VU0099704, selective, protease, activated, receptors, PAR4, antagonists, Protease-Activated, Receptors, 5387, Tocris Bioscience
1 篇 ML 354 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ML 354 的部分引用包括：
Sébert et al (2018) Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism. Br J Pharmacol 175 3656 PMID: 29959891
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