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ML T7

Cat. No. 8119 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3
化学名： 5-(2,4-Dichlorophenyl)-3a,6a-dihydro-3-(4-methylphenyl)spiro[1H-furo[3,4-c]pyrrole-1,2'-[2H]indene]-1',3',4,6(3H,5H)-tetrone
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML T7

ML T7 is a T cell immunoglobulin and mucin-containing molecule 3 (Tim-3) inhibitor; disrupts phosphatidylserine/CAECAM1 binding to Tim-3 (Kd = 7.0 μM and 7.4 μM for hTim-3 and mTim-3 respectively). ML T7 promotes cell proliferation, cytokine production and cytotoxicity of OT-I CD8+ cytotoxic T lymphocytes. ML T7 inhibits tumor growth in a syngeneic mouse model of hepatocellular carcinoma, increases NK cell tumor killing activity and DC maturation.

技术数据 for ML T7

分子量 506.34
公式 C27H17Cl2NO5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 459789-75-4
PubChem ID 3116616
InChI Key OFJOQMMYCMPPEC-UHFFFAOYSA-N
Smiles ClC1=CC=C(C(Cl)=C1)N2C(C(C3C2=O)C(OC43C(C5=C(C4=O)C=CC=C5)=O)C6=CC=C(C=C6)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML T7

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.63 100

制备储备液 for ML T7

以下数据基于产品分子量 506.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.87 mL 19.75 mL
5 mM 0.39 mL 1.97 mL 3.95 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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参考文献 for ML T7

参考文献是支持产品生物活性的出版物。

Ma et al (2023) Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Sci.Transl.Med. 15 PMID: 37967204

If you know of a relevant reference for ML T7, please let us know.

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关键词: ML T7, ML T7 supplier, MLT7, ML, T7, T, cell, immunoglobulin, mucin, Tim3, Tim-3, inhibitor, phosphatidylserine, CEACAM1, cytokine, lymphocytes, HCC, hepatocellular, carcinoma, NK, natural, killer, Immune, Checkpoints, 8119, Tocris Bioscience

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