ML T7

Cat. No. 8119 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3

化学名： 5-(2,4-Dichlorophenyl)-3a,6a-dihydro-3-(4-methylphenyl)spiro[1H-furo[3,4-c]pyrrole-1,2'-[2H]indene]-1',3',4,6(3H,5H)-tetrone

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ML T7

ML T7 is a T cell immunoglobulin and mucin-containing molecule 3 (Tim-3) inhibitor; disrupts phosphatidylserine/CAECAM1 binding to Tim-3 (K_d = 7.0 μM and 7.4 μM for hTim-3 and mTim-3 respectively). ML T7 promotes cell proliferation, cytokine production and cytotoxicity of OT-I CD8+ cytotoxic T lymphocytes. ML T7 inhibits tumor growth in a syngeneic mouse model of hepatocellular carcinoma, increases NK cell tumor killing activity and DC maturation.

技术数据 for ML T7

分子量	506.34
公式	C₂₇H₁₇Cl₂NO₅
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	459789-75-4
PubChem ID	3116616
InChI Key	OFJOQMMYCMPPEC-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(Cl)=C1)N2C(C(C3C2=O)C(OC43C(C5=C(C4=O)C=CC=C5)=O)C6=CC=C(C=C6)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML T7

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	50.63	100

制备储备液 for ML T7

以下数据基于产品分子量 506.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.87 mL	19.75 mL
5 mM	0.39 mL	1.97 mL	3.95 mL
10 mM	0.2 mL	0.99 mL	1.97 mL
50 mM	0.04 mL	0.2 mL	0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for ML T7

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ML T7

参考文献是支持产品生物活性的出版物。

Ma et al (2023) Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Sci.Transl.Med. 15 PMID: 37967204

If you know of a relevant reference for ML T7, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Immune Checkpoint Inhibitors

关键词: ML T7, ML T7 supplier, MLT7, ML, T7, T, cell, immunoglobulin, mucin, Tim3, Tim-3, inhibitor, phosphatidylserine, CEACAM1, cytokine, lymphocytes, HCC, hepatocellular, carcinoma, NK, natural, killer, Immune, Checkpoints, 8119, Tocris Bioscience

篇 ML T7 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 ML T7 的引用文献。您是否知道使用了 Tocris ML T7 的优秀论文？请告知我们.

ML T7 的评论

目前没有该产品的评论。 Be the first to review ML T7 and earn rewards!

Have you used ML T7?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.