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Submit ReviewMMPIP hydrochloride
Discontinued Product
2963 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Potent and selective negative allosteric modulator of mGlu7 receptors
化学名： 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride
纯度： ≥98% (HPLC)
生物活性 for MMPIP hydrochloride
MMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.
技术数据 for MMPIP hydrochloride
| 分子量 | 369.8 |
| 公式 | C19H15N3O3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1215566-78-1 |
| PubChem ID | 52974245 |
| InChI Key | HXHQNERSIJXMTQ-UHFFFAOYSA-N |
| Smiles | O=C1N(C)C(C3=CC=C(OC)C=C3)=CC2=C1C(C4=CC=NC=C4)=NO2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MMPIP hydrochloride
参考文献 for MMPIP hydrochloride
参考文献是支持产品生物活性的出版物。
Suzuki et al (2007) In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J.Pharmacol.Exp.Ther. 323 147 PMID: 17609420
关键词: MMPIP hydrochloride, MMPIP hydrochloride supplier, Potent, allosteric, mGlu7, mGluR7-selective, antagonists, Group, III, Receptors, Glutamate, Metabotropic, NAM, (Metabotropic), 2963, Tocris Bioscience
4 篇 MMPIP hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MMPIP hydrochloride 的部分引用包括：
Jantas et al (2018) New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Neuropharmacology 141 223 PMID: 30170084
Kammermeier (2015) Constitutive activity of metabotropic glutamate receptor 7. Front Pediatr 16 17 PMID: 25881041
Johansson et al (2015) Activation of a temporal memory in purkinje cells by the mGluR7 receptor. Cell Rep. 13 1741 PMID: 26655894
Palazzo et al (2013) Effects of a metabotropic glutamate receptor subtype 7 negative allosteric modulator in the periaqueductal grey on pain responses and rostral ventromedial medulla cell activity in rat. Mol Pain 9 44 PMID: 24004843
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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