MNI-caged-L-glutamate

Cat. No. 1490 61 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Stable photoreleaser of L-glutamate

别名： 4-Methoxy-7-nitroindolinyl-caged-L-glutamate,MNI glutamate

化学名： (S)-α-Amino-2,3-dihydro-4-methoxy-7-nitro-δ-oxo-1H-indole-1-pentanoic acid

纯度： ≥99% (HPLC)

引用文献 (61)

文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MNI-caged-L-glutamate

MNI-caged-L-glutamate is a form of glutamate linked to a photo-protecting group, 4-methoxy-7-nitroindolinyl (MNI); it rapidly and efficiently releases L-glutamate (Cat. No. 0218) by photolysis (300 - 380 nm excitation) with a quantum yield in the 0.065-0.085 range. It is also suitable for use with two-photon uncaging microscopy (cross-section of 0.06 GM at 730 nm). MNI-caged-L-glutamate is optically compatible with other chromophores used for fluorescence imaging, such as GFP, YFP and most Ca²⁺ dyes. MNI-caged-L-glutamate is 2.5-fold more efficient at releasing L-glutamate than NI-caged L-glutamate. MNI-caged-L-glutamate is water-soluble, stable at neutral pH, highly resistant to hydrolysis and pharmacologically inactive at neuronal glutamate receptors and transporters (up to mM concentrations). MNI-caged-L-glutamate can be used for in situ studies of fast synaptic glutamate receptors.

View more information regarding MNI-caged-L-glutamate.

许可信息

Sold under license from the Medical Research Council

技术数据 for MNI-caged-L-glutamate

分子量	323.3
公式	C₁₄H₁₇N₃O₆
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	295325-62-1
PubChem ID	6604871
InChI Key	GXIDBZKXGUNITQ-VIFPVBQESA-N
Smiles	O=C(CC[C@H](N)C(O)=O)N2C1=C([N+]([O-])=O)C=CC(OC)=C1CC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MNI-caged-L-glutamate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	16.16	50

制备储备液 for MNI-caged-L-glutamate

以下数据基于产品分子量 323.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	6.19 mL	30.93 mL	61.86 mL
2.5 mM	1.24 mL	6.19 mL	12.37 mL
5 mM	0.62 mL	3.09 mL	6.19 mL
25 mM	0.12 mL	0.62 mL	1.24 mL

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产品说明书 for MNI-caged-L-glutamate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MNI-caged-L-glutamate

参考文献是支持产品生物活性的出版物。

Canepari et al (2001) Photochemical and pharmacological evaluation of 7-nitroindolinyl- and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters. J.Neurosci.Methods 112 29 PMID: 11640955

Maier et al (2005) Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor. J.Neurosci.Methods 142 1 PMID: 15652611

Matsuzaki et al (2001) Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat.Neurosci. 4 1086 PMID: 11687814

Papageorgiou and Corrie (2000) Effects of aromatic substitutions on the photocleavage of 1-acyl-7-nitroindolines. Tetrahedron 56 8197

Palma-Cerda et al (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 63 624 PMID: 22609535

Ellis-Davies (2019) Two-Photon Uncaging of Glutamate Front Synaptic Neurosci. 10 48 PMID: 30687075

If you know of a relevant reference for MNI-caged-L-glutamate, please let us know.

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关键词: MNI-caged-L-glutamate, MNI-caged-L-glutamate supplier, Stable, photoreleaser, L-glutamate, Caged, Compounds, Glutamate, mGlur, Receptors, Metabotropic, Non-Selective, iGlur, Ionotropic, agonists, MNI, glutamate, MNI-Glutamate, 4-Methoxy-7-nitroindolinyl-caged-L-glutamate, Miscellaneous, Non-selective, mGlu, 1490, Tocris Bioscience

61 篇 MNI-caged-L-glutamate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MNI-caged-L-glutamate 的部分引用包括：

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