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说明： Novel, non-toxic immunosuppressive agent
别名： NSC 631156
化学名： 4-Methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H-1,2,4-triazole
纯度： ≥99% (HPLC)
生物活性 for MNITMT
MNITMT is a novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.
Previously sold as Cat. No. 0564.
技术数据 for MNITMT
| 分子量 | 240.24 |
| 公式 | C7H8N6O2S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 177653-76-8 |
| PubChem ID | 364622 |
| InChI Key | NMBDIMPYACLUDE-UHFFFAOYSA-N |
| Smiles | CN1C=NN=C1SC1=C(N=CN1C)[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MNITMT
参考文献 for MNITMT
参考文献是支持产品生物活性的出版物。
Crawford et al (1996) Rational design of novel immunosuppressive drugs: analogues of azathio. lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. J.Med.Chem. 39 2690 PMID: 8709098
Al-Safi et al (2003) Comparison of the effects of azathio. and its novel non-mercaptopurine analog on antibody response in rabbits. Pol.J.Pharmacol. 55 239 PMID: 12926553
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关键词: MNITMT, MNITMT supplier, Immunosuppressant, NSC631156, NSC, 631156, Immunosuppressants, 2492, Tocris Bioscience
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