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Submit ReviewModafinil
说明： Psychostimulant
别名： CRL 40476
化学名： 2-[(Diphenylmethyl)sulfinyl]acetamide
纯度： ≥98% (HPLC)
生物活性 for Modafinil
Modafinil is a psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Modafinil promotes vigilance and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
技术数据 for Modafinil
| 分子量 | 273.35 |
| 公式 | C15H15NO2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 68693-11-8 |
| PubChem ID | 4236 |
| InChI Key | YFGHCGITMMYXAQ-UHFFFAOYSA-N |
| Smiles | O=S(CC(N)=O)C(C2=CC=CC=C2)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Modafinil
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 20.5 | 75 | |
| ethanol | 2.73 | 10 |
制备储备液 for Modafinil
以下数据基于产品分子量 273.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 4.88 mL | 24.39 mL | 48.78 mL |
| 3.75 mM | 0.98 mL | 4.88 mL | 9.76 mL |
| 7.5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
| 37.5 mM | 0.1 mL | 0.49 mL | 0.98 mL |
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产品说明书 for Modafinil
参考文献 for Modafinil
参考文献是支持产品生物活性的出版物。
Ferraro et al (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and DA uptake blockers. Biol.Psychiatry 42 1181 PMID: 9426889
Jenner et al (2000) Antiparkinsonian and neuroprotective effects of moda. in the mtpt-treated common marmoset. Exp.Brain Res. 133 178 PMID: 10968218
Madras et al (2006) Modafinil occupies DA and NE transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 319 561 PMID: 16885432
If you know of a relevant reference for Modafinil, please let us know.
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关键词: Modafinil, Modafinil supplier, Psychostimulant, Adrenergic, Compounds, Adrenoceptors, Receptors, Dopaminergic, Dopamine, GABA, CRL40476, CRL, 40476, Related, Dopaminergic-Related, Miscellaneous, GABAB, 1811, Tocris Bioscience
1 篇 Modafinil 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Modafinil 的部分引用包括：
Yu et al (2019) Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep 42 PMID: 30722053
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Modafinil 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.