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说明： Selective orthostatic agonist of hFFA2-DREADDs
化学名： 4-Methoxy-3-methylbenzoic acid
纯度： ≥98% (HPLC)
生物活性 for MOMBA
MOMBA is a selective orthosteric agonist for human free fatty acid 2 (hFFA2) engineered receptors, designer receptors activated by designer drugs (DREADD), it shows no activity to wild-type hFFA2, hFFA3, and mouse FFA2. MOMBA inhibit forskolin-stimulated cAMP levels in cells expressing the hFFA2-DREADD receptor with improved potency and equivalent efficacy to Sorbic acid (Cat. No. 7119). In hFFA2-DREADD transgenic mice, MOMBA treatment significantly reduces gut transit and promotes concentration-dependent release of GLP-1 from colonic crypts. Orally bioavailable.
技术数据 for MOMBA
| 分子量 | 166.17 |
| 公式 | C9H10O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 6880-04-2 |
| PubChem ID | 2759583 |
| InChI Key | DNMUMZLKDOZMEY-UHFFFAOYSA-N |
| Smiles | O=C(O)C1=CC=C(OC)C(=C1)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MOMBA
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 16.62 | 100 | |
| ethanol | 16.62 | 100 |
制备储备液 for MOMBA
以下数据基于产品分子量 166.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.02 mL | 30.09 mL | 60.18 mL |
| 5 mM | 1.2 mL | 6.02 mL | 12.04 mL |
| 10 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 50 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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产品说明书 for MOMBA
参考文献 for MOMBA
参考文献是支持产品生物活性的出版物。
Barki et al (2022) Chemogenetics defines a short-chain fatty acid receptor gut-brain axis. Elife 11 e73777 PMID: 35229717
Miura et al (2022) Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches. RSC Chem.Biol. 3 269 PMID: 35359495
Milligan et al (2021) Chemogenetic approaches to explore the functions of free fatty acid receptor 2. Trends Pharmacol.Sci. 42 191 PMID: 33495026
If you know of a relevant reference for MOMBA, please let us know.
关键词: MOMBA, MOMBA supplier, orthostatic, agonist, free, fatty, acid, receptor, 2, FFA2, hFFA2, designer, receptors, activated, by, drugs, DREADD, DREADDs, Free, Fatty, Acid, Receptors, 7926, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.
Allosteric GPCR Pharmacology Poster
G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.
GPCR Efficacy and Biased Agonism Poster
GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.