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Submit ReviewMorphine hydrochloride
说明： Narcotic opioid analgesic
化学名： 7,8-Didehydro-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3,6-diol hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Morphine hydrochloride
Morphine hydrochloride is a narcotic opioid analgesic.
技术数据 for Morphine hydrochloride
| 分子量 | 321.8 |
| 公式 | C17H19NO3.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 52-26-6 |
| PubChem ID | 5464110 |
| InChI Key | XCKKIKBIPZJUET-VYKNHSEDSA-N |
| Smiles | O[C@@H]3[C@H]5[C@]24C1=C(O5)C(O)=CC=C1C[C@@H](N(C)CC4)[C@@]([H])2C=C3.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Morphine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 16.09 | 50 |
制备储备液 for Morphine hydrochloride
以下数据基于产品分子量 321.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.22 mL | 31.08 mL | 62.15 mL |
| 2.5 mM | 1.24 mL | 6.22 mL | 12.43 mL |
| 5 mM | 0.62 mL | 3.11 mL | 6.22 mL |
| 25 mM | 0.12 mL | 0.62 mL | 1.24 mL |
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产品说明书 for Morphine hydrochloride
参考文献 for Morphine hydrochloride
参考文献是支持产品生物活性的出版物。
Merck Index 12 1074
If you know of a relevant reference for Morphine hydrochloride, please let us know.
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关键词: Morphine hydrochloride, Morphine hydrochloride supplier, opioid, receptors, analgesic, Miscellaneous/Non-selective, Opioids, 5158, Tocris Bioscience
4 篇 Morphine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Morphine hydrochloride 的部分引用包括：
Prather et al (2013) CB1 and CB2 receptors are novel molecular targets for tamox. and 4OH-Tamoxifen. Biochem Biophys Res Commun 441 339 PMID: 24148245
Rajasekaran et al (2013) Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. Toxicol Appl Pharmacol 269 100 PMID: 23537664
Mohammad et al (2021) Effects of intrathecal and intracerebroventricular microinjection of kaempferol on pain: possible mechanisms of action. Res Pharm Sci 16 203-216 PMID: 34084207
Jose A et al (2021) An endogenous opioid circuit determines state-dependent reward consumption. Nature 598 646-651 PMID: 34646022
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Morphine hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
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Morphine inhibits AITC-induced p42/44 phosphorylation in brain.
By
Christopher Trummer on 10/15/2018
分析类型： In Vivo
种属： Mouse
细胞系/组织： Brain
Saline or morphine (10 mg/kg, s.c.) was injected 1 h prior to intrarectal instillation of peanut oil (Veh) or AITC 2% (v/v) in mice. Phosphorylation of p42/44 was analysed in spinal cord (Sc), thalamus (Th), hypothalamus (Hth), amygdala (Amy), and prefrontal cortex (Pfc) lysates using Western blot. Morphine significantly inhibited AITC-induced pp42/44 expression (shown in Image).
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