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说明： Potent inhibitor of L-glutamate uptake. Less activity as a substrate compared to its parent compound, L-trans-2,4-PDC (Cat. No. 0298)
化学名： L-anti-endo-3,4-Methanopyrrolidinedicarboxylic acid
生物活性 for MPDC
Potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter.
技术数据 for MPDC
| 分子量 | 171.15 |
| 公式 | C7H9NO4 |
| 储存 | Store at RT |
| CAS Number | 159262-32-5 |
| PubChem ID | 6604785 |
| InChI Key | UNNFLFDQCHJXPI-QTBDOELSSA-N |
| Smiles | [H][C@]1([C@H]2[C@@](O)=O)[C@]2([H])CN[C@@H]1[C@](O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MPDC
参考文献 for MPDC
参考文献是支持产品生物活性的出版物。
Bridges et al (1994) A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: L-anti-endo-3,4-methanopyrrolidine carboxylate. Neurosci.Lett. 174 193 PMID: 7970177
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关键词: MPDC, MPDC supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, 0973, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.