主页 / 药理学 / Ion Channels / Transient Receptor Potential Channels / TRPV Channels / TRPV Channel Modulators / MRS 1477

MRS 1477

Cat. No. 5246 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5246 has been discontinued.

View all TRPV Channels products.
说明： TRPV1 positive allosteric modulator
化学名： 4-Ethyl-1,4-dihydro-5-[[(2-methoxyethyl)thio]carbonyl]-6-methyl-2-phenyl-3-pyridinecarboxylic acid ethyl ester
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for MRS 1477

TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin (Cat. No. 0462) in rats. Also prolongs capsaicin-induced hypothermia in mice.

技术数据 for MRS 1477

分子量 389.51
公式 C21H27NO4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 212200-21-0
PubChem ID 9843337
InChI Key DMVMFYWYJCPZGS-UHFFFAOYSA-N
Smiles CCC1C(C(OCC)=O)=C(C2=CC=CC=C2)NC(C)=C1C(SCCOC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for MRS 1477

参考文献是支持产品生物活性的出版物。

Kaszas et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J.Pharmacol.Exp.Ther. 340 152 PMID: 22005042

Lebovitz et al (2012) Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Mol.Pain 8 PMID: 22998799

Roh et al (2008) Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorg.Med.Chem. 16 9349 PMID: 18809334

按标靶查看相关产品

按产品操作查看相关产品

查看全部 TRPV Channel Modulators

关键词: MRS 1477, MRS 1477 supplier, MRS1477, TRPV1, transient, receptors, potential, channels, positive, allosteric, modulators, analgesic, PAM, TRPV, 5246, Tocris Bioscience

篇 MRS 1477 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 MRS 1477 的引用文献。

MRS 1477 的评论

目前没有该产品的评论。 Be the first to review MRS 1477 and earn rewards!

Have you used MRS 1477?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review