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Submit ReviewMRS 1706
Discontinued Product
1584 has been discontinued.
View all Adenosine A<sub>2B</sub> Receptors products.
说明： Potent and selective A2B inverse agonist
化学名： N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
纯度： ≥96% (HPLC)
生物活性 for MRS 1706
MRS 1706 is a potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively).
许可信息
Manufactured and sold under license from Adenosine Therapeutics, LLC
技术数据 for MRS 1706
| 分子量 | 503.56 |
| 公式 | C27H29N5O5 |
| 储存 | Store at +4°C |
| 纯度 | ≥96% (HPLC) |
| CAS Number | 264622-53-9 |
| PubChem ID | 5139184 |
| InChI Key | ZKUCFFYOQOJLGT-UHFFFAOYSA-N |
| Smiles | O=C(C(NC(C3=CC=C(OCC(NC4=CC=C(C(C)=O)C=C4)=O)C=C3)=N2)=C2N1CCC)N(CCC)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MRS 1706
参考文献 for MRS 1706
参考文献是支持产品生物活性的出版物。
Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 43 1165 PMID: 10737749
Li et al (2007) ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J.Pharmacol.Exp.Ther. 320 637 PMID: 17077318
Kiec-Kononowicz et al (2001) New developments in A1 and A2 adenosine receptor antagonists. Pure Appl.Chem. 73 1411
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关键词: MRS 1706, MRS 1706 supplier, Potent, selective, A2B, inverse, agonists, Receptors, adenosines, MRS1706, Adenosine, 1584, Tocris Bioscience
14 篇 MRS 1706 的引用文献
引用文献是使用了 Tocris 产品的出版物。 MRS 1706 的部分引用包括：
Eusemann et al (2015) Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS One 10 e0134934 PMID: 26263491
Rizvi et al (2013) Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol 59 144 PMID: 24050945
Epperson et al (2009) Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol 296 C1171 PMID: 19244482
Xi et al (2009) Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol 47 684 PMID: 19695259
Clark et al (2009) Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. J Neurosci 29 11237 PMID: 19741130
Schneider et al (2010) Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease. FASEB J 24 70 PMID: 19720619
Mandapathil et al (2010) Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. J Biol Chem 285 7176 PMID: 19858205
Long et al (2010) Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Neurosci 335 781 PMID: 20855445
Lee et al (2012) Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study. Front Neurosci 63 340 PMID: 23115687
Kinoshita et al (2018) Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes. EBioMedicine 32 72 PMID: 29887330
Wakisaka et al (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol 27 1437 PMID: 28502661
Li et al (2014) Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci 31 237 PMID: 24844306
Newman (2005) Calcium increases in retinal glial cells evoked by light-induced neuronal activity. Korean J Anesthesiol 25 5502 PMID: 15944378
Ryzhov et al (2008) Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. J Immunol 180 7212 PMID: 18490720
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