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MRS 1754

Cat. No. 2752 16 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective A2B antagonist
化学名： N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (16)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MRS 1754

MRS 1754 is a selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).

许可信息

Sold with the permission of the University of Virginia Patent Foundation

技术数据 for MRS 1754

分子量 486.52
公式 C26H26N6O4
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 264622-58-4
PubChem ID 6603931
InChI Key AJBBEYXFRYFVNM-UHFFFAOYSA-N
Smiles CCCN1C2=C(NC(=N2)C2=CC=C(OCC(=O)NC3=CC=C(C=C3)C#N)C=C2)C(=O)N(CCC)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MRS 1754

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.43 5 温和加热

制备储备液 for MRS 1754

以下数据基于产品分子量 486.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 41.11 mL 205.54 mL 411.08 mL
0.25 mM 8.22 mL 41.11 mL 82.22 mL
0.5 mM 4.11 mL 20.55 mL 41.11 mL
2.5 mM 0.82 mL 4.11 mL 8.22 mL

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产品说明书 for MRS 1754

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for MRS 1754

参考文献是支持产品生物活性的出版物。

Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 43 1165 PMID: 10737749

Ji et al (2001) [3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors. Biochem.Pharmacol. 61 657 PMID: 11266650

Nemeth et al (2007) Adenosine receptor activation ameliorates type I diabetes. FASEB J. 21 2380

If you know of a relevant reference for MRS 1754, please let us know.

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关键词: MRS 1754, MRS 1754 supplier, Selective, A2B, antagonists, Receptors, adenosines, MRS1754, Adenosine, 2752, Tocris Bioscience

16 篇 MRS 1754 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MRS 1754 的部分引用包括：

Wakisaka et al (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol 27 1437 PMID: 28502661

Zhan et al (2011) Adenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection. Am J Physiol Heart Circ Physiol 301 H1183 PMID: 21743001

Hua et al (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One 6 e24947 PMID: 21966389

Wolk et al (2008) Influenza A virus inhibits alveolar fluid clearance in BALB/c mice. PLoS One 178 969 PMID: 18689466

Lemos et al (2015) Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain. Purinergic Signal 11 561 PMID: 26446689

Yu et al (2009) Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice. Am J Respir Crit Care Med 297 L785 PMID: 19684202

Asano (2017) Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. Scientific Reports 7 40214 PMID: 28054654

He et al (2013) Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J 27 3446 PMID: 23682121

Garção et al (2013) Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum. Br J Pharmacol 169 1600 PMID: 23638679

Kan et al (2012) Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol 86 10338 PMID: 22787201

Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling PMID: 27577957

Gebremedhin et al (2010) Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab 30 1777 PMID: 20531463

Liu et al (2018) Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res 1700 47 PMID: 29935155

Kohno et al (2015) Anti-inflammatory effects of adenosine N1-oxide. Am J Physiol Lung Cell Mol Physiol 12 2 PMID: 25632271

Welihinda and Amento (2014) Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond) 11 37 PMID: 25473378

Pedroza et al (2011) Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury. Mol Vis 6 e22667 PMID: 21799929

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