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MRS 1845

Cat. No. 1866 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1866 has been discontinued.

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说明： Potent SOCE inhibitor; blocks capacitative Ca2+ entry
别名： N-Propylargylnitrendipine
化学名： 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylic acid ethyl, methyl ester
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for MRS 1845

Potent blocker of store-operated Ca2+ channels; inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM).

技术数据 for MRS 1845

分子量 398.41
公式 C21H22N2O6
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 544478-19-5
PubChem ID 11538542
InChI Key BITHABUTZRAUGT-UHFFFAOYSA-N
Smiles O=C(OCC)C1=C(C)N(CC#C)C(C)=C(C(OC)=O)C1C2=CC([N+]([O-])=O)=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for MRS 1845

分析证书/产品说明书
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参考文献 for MRS 1845

参考文献是支持产品生物活性的出版物。

Harper et al (2003) Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. Biochem.Pharmacol. 65 329 PMID: 12527326

Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS ONE 4 e6723 PMID: 19696927

Szikra et al (2008) Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors. J.Physiol. 586 4859 PMID: 18755743

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关键词: MRS 1845, MRS 1845 supplier, Potent, SOC, inhibitors, inhibits, blocks, capacitative, Ca2+, entry, Calcium, Signaling, Signalling, Agents, General, Channels, Store-Operated, MRS1845, N-Propylargylnitrendipine, Other, STIM-Orai, 1866, Tocris Bioscience

1 篇 MRS 1845 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MRS 1845 的部分引用包括：

Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180 PMID: 24312407

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