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MU 1700 trihydrochloride

Cat. No. 8832 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective ALK1/2 inhibitor. Brain-penetrant
化学名： 6-(4-Piperazin-1-ylphenyl)-3-quinolin-4-ylfuro[3,2-b]pyridine trihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for MU 1700 trihydrochloride

MU 1700 trihydrochloride is a potent and selective ALK2 and ALK1 inhibitor (IC50 values are 6 nM and 13 nM, respectively in biochemical assays). It is also a potent ALK6 inhibitor (IC50 = 41 nM). It shows selectivity for ALK over >360 other kinases. It shows favorable pharmacokinetic for in vivo use. MU 1700 trihydrochloride is orally bioavailable. It is cell membrane permeable and brain penetrant.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1700 probe summary on the SGC website.

技术数据 for MU 1700 trihydrochloride

分子量 515.86
公式 C26H22N4O.3HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key RRVVHPUANQAUJY-UHFFFAOYSA-N
Smiles C12=C(C=CC=C2)N=CC=C1C3=COC4=C3N=CC(C5=CC=C(C=C5)N6CCNCC6)=C4.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MU 1700 trihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.16 10
water 25.79 50

制备储备液 for MU 1700 trihydrochloride

以下数据基于产品分子量 515.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.88 mL 19.39 mL 38.77 mL
2.5 mM 0.78 mL 3.88 mL 7.75 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
25 mM 0.08 mL 0.39 mL 0.78 mL

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产品说明书 for MU 1700 trihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for MU 1700 trihydrochloride

参考文献是支持产品生物活性的出版物。

Němec et al (2024) Discovery of two highly selective structurally orthogonal chemical probes for activin receptor-like kinases 1 and 2. J.Med.Chem. 67 12632 PMID: 39023313

If you know of a relevant reference for MU 1700 trihydrochloride, please let us know.

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关键词: MU 1700 trihydrochloride, MU 1700 trihydrochloride supplier, MU1700, 3HCl, MU-1700, potent, selective, alk, inhibitors, inhibits, kinases, tyrosine, kinase, 2, ALK, ALK1, ALK2, ALK6, orally, bioavailable, brain, penetrant, in, vivo, 8832, Tocris Bioscience

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