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说明： Irreversible TrxR inhibitor
化学名： 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
纯度： ≥97% (HPLC)
生物活性 for Myricetin
Myricetin is an irreversible TrxR inhibitor (IC50 = 0.62 μM). Exhibits concentration-, time- and NADH-dependent TrxR inhibition. Results in the oxidation of Trx and reduced TrxR activity in vitro in addition to the accumulation of cells in sub-G1 phase. Reduces neoplastic transformation and induces cell death in cancer cell lines. Chemotherapeutic. Myricetin binds to the CAG motif of the mutant RNA from the HTT gene in Huntington's disease (HD). It prevents the translation of mutant huntingtin protein as well as sequestration of MBNL1. Myricetin alleviates proteotoxicity of expanded polyglutamine proteins in Cos-7 cells. Myricetin also improves neurobehavioral deficits in the HD mouse model.
技术数据 for Myricetin
| 分子量 | 318.24 |
| 公式 | C15H10O8 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 529-44-2 |
| PubChem ID | 5281672 |
| InChI Key | IKMDFBPHZNJCSN-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C2C(OC(C3=CC(O)=C(C(O)=C3)O)=C(C2=O)O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Myricetin
参考文献 for Myricetin
参考文献是支持产品生物活性的出版物。
Lu et al (2006) Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer.Res. 66 4410 PMID: 16618767
Lu & Holmgren et al (2009) Selenoproteins. J.Biol.Chem. 284 723 PMID: 18757362
Ko et al (2005) Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. Biochem.Pharmacol. 69 913 PMID: 15748703
Devi et al (2015) Molecular mechanisms underlying anticancer effects of myricetin. Life.Sci. 142 19 PMID: 26455550
Ong & Khoo et al (1997) Biological effects of myricetin. Gen.Pharmacol. 29 121 PMID: 9251891
Khan et al (2018) Myricetin reduces toxic level of CAG repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs). ACS Chem.Biol. 13 180 PMID: 29172480
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