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Submit ReviewN-Acetylcysteine amide
说明： Glutathione (GSH) precursor; neuroprotective
化学名： (2R)-2-(Acetylamino)-3-mercaptopropanamide
生物活性 for N-Acetylcysteine amide
N-Acetylcysteine amide is a glutathione (GSH) precursor and cell-permeable antioxidant. N-Acetylcysteine amide replenishes intracellular Glutathione (GSH). N-Acetylcysteine amide directly reduces intracellular Glutathione disulfide (GSSG) to GSH without glutathione peroxidase. N-Acetylcysteine amide has anti-inflammatory activity through regulation of activation of NF-κB and HIF-1α, as well as modulation of reactive oxygen species. N-Acetylcysteine amide improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances functional recovery following spinal cord injury in rats. N-Acetylcysteine amide also enhances behavioral recovery in rats following traumatic brain injury. Neuroprotective.
For more information about how N-Acetylcysteine amide may be used, see our protocol: 3D Culture of Lung Alveolar Cells
技术数据 for N-Acetylcysteine amide
| 分子量 | 162.21 |
| 公式 | C5H10N2O2S |
| 储存 | Store at -20°C |
| CAS Number | 38520-57-9 |
| PubChem ID | 10176265 |
| InChI Key | UJCHIZDEQZMODR-BYPYZUCNSA-N |
| Smiles | SC[C@H](NC(C)=O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for N-Acetylcysteine amide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 16.22 | 100 | |
| DMSO | 16.22 | 100 |
制备储备液 for N-Acetylcysteine amide
以下数据基于产品分子量 162.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.16 mL | 30.82 mL | 61.65 mL |
| 5 mM | 1.23 mL | 6.16 mL | 12.33 mL |
| 10 mM | 0.62 mL | 3.08 mL | 6.16 mL |
| 50 mM | 0.12 mL | 0.62 mL | 1.23 mL |
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产品说明书 for N-Acetylcysteine amide
参考文献 for N-Acetylcysteine amide
参考文献是支持产品生物活性的出版物。
Patel et al (2014) N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma. Exp.Neurol. 257 95 PMID: 24805071
Pandya et al (2014) N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp.Neurol. 257 106 PMID: 24792639
Tu et al (2019) The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases. Aging Dis 10 637 PMID: 31165007
If you know of a relevant reference for N-Acetylcysteine amide, please let us know.
关键词: N-Acetylcysteine amide, N-Acetylcysteine amide supplier, cell, permeable, antioxidant, neuroprotective, glutathione, precursor, GSH, organoids, hematopoietic, haematopoietic, stem, cells, HSC, Antioxidants, Hematopoietic, Stem, Cells, 5619, Tocris Bioscience
5 篇 N-Acetylcysteine amide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 N-Acetylcysteine amide 的部分引用包括：
Tao et al (2021) Microengineered multi-organoid system from hiPSCs to recapitulate human liver-islet axis in normal and type 2 diabetes. Adv.Sci. 9 e2103495 PMID: 34951149
Gutierrez et al (2014) The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem 289 33568 PMID: 25301941
Christian et al (2021) NF-κB determines Paneth versus goblet cell fate decision in the small intestine. Development 148 PMID: 34751748
Craig et al (2022) Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia. Acta Neuropathol Commun 10 40 PMID: 35346366
Young-Min et al (2020) Nanosphere Loaded with Curcumin Inhibits the Gastrointestinal Cell Death Signaling Pathway Induced by the Foodborne Pathogen Vibrio vulnificus. Cells 9 PMID: 32151068
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NAC inhibits HOCl-LDL-induced CaMKII oxidation.
By
Chintan Koyani on 10/22/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Cardiomyocytes
HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.
