N-Acetylcysteine

Cat. No. 7874 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Glutathione (GSH) precursor; maintains stem cell function in culture.

化学名： (2R)-2-Acetamido-3-sulfanylpropanoic acid

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for N-Acetylcysteine

N-Acetylcysteine is a cell-permeable antioxidant and a precursor of reduced glutathione (GSH) (Cat. No. 5219), with anti-inflammatory, mucolytic, and antiviral activities. N-Acetylcysteine can be used in organoid culture media for non-small cell lung and colorectal cancer organoids, expansion media for mouse/human liver and pancreas 3D organoids and LWRN media for colonic 3D organoids from human biopsies. It is a component of S7 medium in the optimized protocol for generation of functional stem cell-derived islets (SC-islets). N-Acetylcysteine can be orally administered.

技术数据 for N-Acetylcysteine

分子量	163.2
公式	C₅H₉NO₃S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	616-91-1
PubChem ID	12035
InChI Key	PWKSKIMOESPYIA-BYPYZUCNSA-N
Smiles	[C@@H](NC(C)=O)(C(O)=O)CS

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for N-Acetylcysteine

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	8.16	50
	water	8.16	50

制备储备液 for N-Acetylcysteine

以下数据基于产品分子量 163.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	12.25 mL	61.27 mL	122.55 mL
2.5 mM	2.45 mL	12.25 mL	24.51 mL
5 mM	1.23 mL	6.13 mL	12.25 mL
25 mM	0.25 mL	1.23 mL	2.45 mL

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产品说明书 for N-Acetylcysteine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for N-Acetylcysteine

参考文献是支持产品生物活性的出版物。

Cattaneo et al (2019) Tumor organoid-T-cell coculture systems. Nat.Protoc. 15 15 PMID: 31853056

Broutier et al (2016) Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation. Nat.Protoc. 11 1724 PMID: 27560176

Balboa et al (2022) Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells. Nat.Biotechnol. 40 1042 PMID: 35241836

Moiseeva et al (2023) Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Nature 613 169 PMID: 36544018

Geiler et al (2009) N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus. Biochem.Pharmacol. 79 413 PMID: 19732754

If you know of a relevant reference for N-Acetylcysteine, please let us know.

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