N-Arachidonyl maleimide

Name: N -Arachidonyl maleimide
Brand: Tocris Bioscience
SKU: 3329

Cat. No. 3329 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3329 has been discontinued.

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说明： Potent, competitive MAGL inhibitor

化学名： 1-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yl-1H-pyrrole-2,5-dione

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for N-Arachidonyl maleimide

Potent, competitive and irreversible monoacylglycerol lipase (MAGL) inhibitor (IC₅₀ = 140 nM). Selectively prevents metabolic inactivation of 2-arachidonoylglycerol (2-AG) by ~ 85% and increases the potency of 2-AG in mouse cerebellum in vitro.

技术数据 for N-Arachidonyl maleimide

分子量	369.54
公式	C₂₄H₃₅NO₂
储存	Store at -80°C
纯度	≥98% (HPLC)
CAS Number	876305-42-9
Smiles	O=C1C=CC(N1CCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for N-Arachidonyl maleimide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for N-Arachidonyl maleimide

参考文献是支持产品生物活性的出版物。

Saario et al (2005) Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem.Biol. 12 649 PMID: 15975510

Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem.Biol. 14 1347 PMID: 18096503

Burston et al (2008) N-arachidonyl maleimide potentiates the pharmalocogical and biochemical effects of the endocannabinoid 2-arachidonylyglycerol through inhibition of monoacylglycerol lipase. J.Pharmacol.Exp.Ther. 327 546 PMID: 18682568

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关键词: N-Arachidonyl maleimide, N-Arachidonyl maleimide supplier, Potent, competitive, MAGL, inhibitors, inhibits, Monoacylglycerol, Lipases, Esterases, MGL, 3329, Tocris Bioscience

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