N-Nonyldeoxynojirimycin

Cat. No. 3691 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Glucosidase inhibitor

别名： NN-DNJ

化学名： (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for N-Nonyldeoxynojirimycin

N-Nonyldeoxynojirimycin is a glucosidase inhibitor (IC₅₀ values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.

技术数据 for N-Nonyldeoxynojirimycin

分子量	289.41
公式	C₁₅H₃₁NO₄
储存	Store at -20°C
CAS Number	81117-35-3
PubChem ID	501640
InChI Key	FTSCEGKYKXESFF-LXTVHRRPSA-N
Smiles	O[C@H]1[C@H](O)[C@@H](CO)N(CCCCCCCCC)C[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for N-Nonyldeoxynojirimycin

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	28.94	100
	ethanol	28.94	100

制备储备液 for N-Nonyldeoxynojirimycin

以下数据基于产品分子量 289.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.46 mL	17.28 mL	34.55 mL
5 mM	0.69 mL	3.46 mL	6.91 mL
10 mM	0.35 mL	1.73 mL	3.46 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

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产品说明书 for N-Nonyldeoxynojirimycin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for N-Nonyldeoxynojirimycin

参考文献是支持产品生物活性的出版物。

Andersson et al (2004) Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 67 697 PMID: 14757169

Mellor et al (2004) Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 381 867 PMID: 15128289

Sawkar et al (2002) Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA 99 15428

If you know of a relevant reference for N-Nonyldeoxynojirimycin, please let us know.

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