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Submit ReviewN20C hydrochloride
说明： Non-competitive NMDA open-channel blocker
化学名： 2-[(3,3-Diphenylpropyl)amino]acetamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for N20C hydrochloride
Selective, non-competitive NMDA receptor antagonist (IC50 = 5 μM); binds to the receptor-associated ion channel and prevents glutamate-induced Ca2+ influx. Displays neuroprotective activity in vivo. Brain-penetrant.
技术数据 for N20C hydrochloride
| 分子量 | 304.82 |
| 公式 | C17H20N2O.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1177583-87-7 |
| PubChem ID | 16759164 |
| InChI Key | JCJDLPUASJEVRN-UHFFFAOYSA-N |
| Smiles | Cl.NC(=O)CNCCC(C1=CC=CC=C1)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for N20C hydrochloride
参考文献 for N20C hydrochloride
参考文献是支持产品生物活性的出版物。
Planells-Cases et al (2002) A novel N-MthD.-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J.Pharmacol.Exp.Ther. 302 163 PMID: 12065713
关键词: N20C hydrochloride, N20C hydrochloride supplier, Non-competitive, NMDA, receptor, open-channel, blockers, glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 2213, Tocris Bioscience
1 篇 N20C hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 N20C hydrochloride 的部分引用包括：
Roy et al (2014) Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. J Biol Chem 9 e101883 PMID: 25007337
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