NAADP tetrasodium salt

Cat. No. 3905 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Ca²⁺ mobilizing agent

别名： NAADP

化学名： Nicotinic acid adenine dinucleotide phosphate tetrasodium salt

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NAADP tetrasodium salt

NAADP tetrasodium salt is a Ca²⁺ mobilizing agent. Initiates Ca²⁺ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca²⁺ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca²⁺ from acidic organelles.

技术数据 for NAADP tetrasodium salt

分子量	832.32
公式	C₂₁H₂₃N₆Na₄O₁₈P₃
储存	Store at -20°C
纯度	≥98% (HPLC)
PubChem ID	90488897
InChI Key	NWKIGVGTZIAOCW-MCNGMCCKSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].NC1=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]4=CC(=CC=C4)C([O-])=O)[C@@H](O)[C@H]3OP([O-])([O-])=O)C2=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NAADP tetrasodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	41.62	50

制备储备液 for NAADP tetrasodium salt

以下数据基于产品分子量 832.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	2.4 mL	12.01 mL	24.03 mL
2.5 mM	0.48 mL	2.4 mL	4.81 mL
5 mM	0.24 mL	1.2 mL	2.4 mL
25 mM	0.05 mL	0.24 mL	0.48 mL

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产品说明书 for NAADP tetrasodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NAADP tetrasodium salt

参考文献是支持产品生物活性的出版物。

Calcraft et al (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459 596 PMID: 19387438

Dammerman et al (2009) NAADP-mediated Ca²⁺ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci. 106 10678

Galion (2006) NAADP, a new intracellular messenger that mobilizes Ca²⁺ from acidic stores. Biochem.Soc.Transactions 34 922

If you know of a relevant reference for NAADP tetrasodium salt, please let us know.

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