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Submit ReviewNaloxone 3-glucuronide carbonic acid salt
说明： Naloxone conjugate
化学名： (5α)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl β-D-glucopyranosiduronic acid carbonic acid salt
纯度： ≥98% (HPLC)
生物活性
Naloxone 3-glucuronide carbonic acid salt is a Naloxone conjugate. Following oral administration induces delayed diarrhea, as well as milder and delayed withdrawal behavior and tail skin temperature (TST) response compared with naloxone in morphine-dependent rats.
技术数据
| 分子量 | 565.52 |
| 公式 | C25H29NO10.H2CO3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| PubChem ID | 121513881 |
| InChI Key | JWCWXAGEJDGZRX-IDUKCLALSA-N |
| Smiles | O=C(O)O.O=C3[C@H]5[C@]26C1=C(O5)C(OC4OC(C(O)=O)C(O)C(O)C4O)=CC=C1C[C@@H](N(CC6)CC=C)[C@@](O)2CC3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书
参考文献
参考文献是支持产品生物活性的出版物。
Simpkins et al (1988) Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. J.Pharmacol.Exp.Ther. 244 195 PMID: 3335997
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关键词: Naloxone 3-glucuronide carbonic acid salt, Naloxone 3-glucuronide carbonic acid salt supplier, constipation, opioids, diarrhea, narcotics, glucuronide, conjugates, TST, tail, skin, temperature, Miscellaneous/Non-selective, Opioids, 5684, Tocris Bioscience
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