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Submit ReviewNaloxone benzoylhydrazone
说明： Full κ agonist, partial μ and δ agonist and antagonizes agonist-induced activation of NOP
别名： NalBzOH
化学名： [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene] benzoic acid hydrazide
纯度： ≥99% (HPLC)
生物活性 for Naloxone benzoylhydrazone
Naloxone benzoylhydrazone is a mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ, a partial agonist at μ and δ opioid receptors (pEC50 values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [35S]GTPγS binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ-, μ- and δ-mediated analgesia and blocks NOP-induced supraspinal nociception.
技术数据 for Naloxone benzoylhydrazone
| 分子量 | 445.52 |
| 公式 | C26H27N3O4 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 119630-94-3 |
| PubChem ID | 9601084 |
| InChI Key | AKXCFAYOTIEFOH-XTNAHFASSA-N |
| Smiles | O[C@@]23[C@@]([C@]5([H])/C(CC3)=N/NC(C6=CC=CC=C6)=O)(CC4)C1=C(O5)C(O)=CC=C1C[C@H]2N4CC=C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Naloxone benzoylhydrazone
参考文献 for Naloxone benzoylhydrazone
参考文献是支持产品生物活性的出版物。
Connor and Kitchen (2006) Has the sun set on κ3-opioid receptors? Br.J.Pharmacol 147 349 PMID: 16402044
Gistrak et al (1989) Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone J.Pharmacol.Exp.Ther. 251 469 PMID: 2553921
Olianas et al (2006) Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br.J.Pharmacol. 147 360 PMID: 16402046
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关键词: Naloxone benzoylhydrazone, Naloxone benzoylhydrazone supplier, κ-opioid, kappa-opioid, agonists, partial, μ-opioid, mu-opioid, δ-opioid, delta-opioid, antagonists, NOP, Opioids, Receptors, NalBzOH, Miscellaneous/Non-selective, 1419, Tocris Bioscience
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