Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewNaloxone hydrochloride
说明： Non-selective opioid antagonist
化学名： (5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Naloxone hydrochloride
Naloxone hydrochloride is an opioid antagonist.
技术数据 for Naloxone hydrochloride
| 分子量 | 363.84 |
| 公式 | C19H21NO4.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 357-08-4 |
| PubChem ID | 5464092 |
| InChI Key | RGPDIGOSVORSAK-STHHAXOLSA-N |
| Smiles | Cl.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC=C)CC[C@@]14[C@@]5(O)CCC2=O)=CC=C3O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Naloxone hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 36.38 | 100 |
制备储备液 for Naloxone hydrochloride
以下数据基于产品分子量 363.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.74 mL | 27.48 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.5 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.75 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Naloxone hydrochloride
参考文献 for Naloxone hydrochloride
参考文献是支持产品生物活性的出版物。
Pinelli and Trivulzio (1997) Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with mor. and injected with naloxone, in the absence or presence of the antiabstinence agent clon. J.Pharmacol.Toxicol.Methods 38 117 PMID: 9523765
Spivak et al (1997) Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid cavity. Mol.Pharmacol. 52 983 PMID: 9415708
Olson et al (1996) Endogenous opiates: 1995. Peptides 17 1421
Merck Index 12 6449
If you know of a relevant reference for Naloxone hydrochloride, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: Naloxone hydrochloride, Naloxone hydrochloride supplier, Broad, spectrum, opioid, antagonists, Receptors, Miscellaneous/Non-selective, Opioids, 0599, Tocris Bioscience
32 篇 Naloxone hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Naloxone hydrochloride 的部分引用包括：
Francois et al (2017) A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins. Neuron 93 822 PMID: 28162807
Zhou et al (2013) Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem 288 36703 PMID: 24187130
Moser and Giesler (2013) Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J Neurosci 33 6093 PMID: 23554490
Cheng et al (2009) Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats. Proc Natl Acad Sci U S A 2011 159209 PMID: 19729491
Cruz et al (2008) Absence and rescue of mor. withdrawal in GIRK/Kir3 knock-out mice. J Neurosci 28 4069 PMID: 18400906
Pedersen et al (2021) A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol Chem 296 100503 PMID: 33684444
Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. Neuropsychopharmacology 20 1298 PMID: 24574803
Wang et al (2015) Bupren.-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. Nature 19 2587 PMID: 26153065
Koch et al (2015) Hypothalamic POMC neurons promote cannabinoid-induced feeding. J Neurosci 519 45 PMID: 25707796
Navratilova et al (2015) Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. Front Endocrinol (Lausanne) 35 7264 PMID: 25948274
Levoye et al (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. PLoS One 6 167 PMID: 26617570
Chen et al (2015) Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. Psychopharmacology (Berl) 10 e0145556 PMID: 26700862
Kelly et al (2015) The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. World J Gastroenterol 232 305 PMID: 24973897
Yi et al (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. PLoS One 22 49 PMID: 26150021
Pereira et al (2015) Endogenous Opioid-Masked Latent Pain Sensitization: Studies from Mouse to Human. Proc Natl Acad Sci U S A 10 e0134441 PMID: 26305798
Marti et al (2013) Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111. Br J Pharmacol 168 863 PMID: 22994368
Largent-Milnes et al (2013) Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. J Pharmacol Exp Ther 347 7 PMID: 23860305
Gross et al (2010) Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. Am J Physiol Heart Circ Physiol 298 H2201 PMID: 20400686
Hauser et al (2018) Pharmacogenomics of GPCR Drug Targets. Cell 172 41 PMID: 29249361
Largent-Milnes et al (2010) Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol 161 986 PMID: 20977451
Wang et al (2018) Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron 98 90 PMID: 29576387
Jeong et al (2018) Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. PLoS Biol 16 e2004399 PMID: 29689050
Navratilova et al (2012) Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. FASEB J 109 20709 PMID: 23184995
Liu et al (2015) Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats. J Biomed Sci 22 79 PMID: 26385355
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. J Biomed Sci 38 1296 PMID: 23348063
Ali (2011) CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol 105 1051 PMID: 21123660
Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530 PMID: 15140923
Proudfoot et al (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16 1591 PMID: 16920620
Patel et al (2007) Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. Nat Commun 21 1565 PMID: 17272740
García-Fuster et al (2007) Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. J Cell Mol Med 32 399 PMID: 16482086
Moore et al (2003) Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses. Neuropsychopharmacology 100 14397 PMID: 14608033
您是否知道使用了 Tocris Naloxone hydrochloride 的优秀论文？ 请告知我们.
Naloxone hydrochloride 的评论
目前没有该产品的评论。 Be the first to review Naloxone hydrochloride and earn rewards!
Have you used Naloxone hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.