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Submit ReviewNaltrexone hydrochloride
说明： Non-selective opioid antagonist
化学名： (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydromorphinan-6-one hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Naltrexone hydrochloride
Naltrexone hydrochloride is an opioid antagonist.
技术数据 for Naltrexone hydrochloride
| 分子量 | 377.87 |
| 公式 | C20H23NO4.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 16676-29-2 |
| PubChem ID | 11957643 |
| InChI Key | RHBRMCOKKKZVRY-ITLPAZOVSA-N |
| Smiles | Cl.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CCC2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Naltrexone hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 37.79 | 100 |
制备储备液 for Naltrexone hydrochloride
以下数据基于产品分子量 377.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.23 mL | 26.46 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.29 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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产品说明书 for Naltrexone hydrochloride
参考文献 for Naltrexone hydrochloride
参考文献是支持产品生物活性的出版物。
Gold et al (1982) Naltrexone, opiate addiction, and endorphins. Med.Res.Rev. 2 211 PMID: 6289026
Tempel et al (1982) Supersensitivity of brain opiate receptor subtypes after chronic naltr. treatment. Life Sci. 31 1401 PMID: 6292636
Zukin et al (1982) Naltrexone-induced opiate receptor supersensitivity. Brain Res. 245 285 PMID: 6289965
If you know of a relevant reference for Naltrexone hydrochloride, please let us know.
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关键词: Naltrexone hydrochloride, Naltrexone hydrochloride supplier, Broad, spectrum, antagonists, Opioids, Receptors, Miscellaneous/Non-selective, 0677, Tocris Bioscience
9 篇 Naltrexone hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Naltrexone hydrochloride 的部分引用包括：
Leskelä et al (2012) Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. J Biol Chem 287 5008 PMID: 22184124
Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141
Smith et al (2016) Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice. Proc Natl Acad Sci U S A 113 13893 PMID: 27849613
Chung et al (2010) Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice. Hum Mol Genet 11 847 PMID: 20418186
Yue et al (2008) Sustained mor. treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner. Eur J Pharmacol 584 272 PMID: 18328477
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511
Tumati et al (2009) Sustained mor. treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner. J Pain 330 810 PMID: 19491327
Cho et al (2019) Latent Sensitization in a Mouse Model of Ocular Neuropathic Pain. Transl Vis Sci Technol 8 6 PMID: 30937216
Wang et al (2010) Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A 107 13117 PMID: 20615975
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.