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Submit ReviewNaltrindole hydrochloride
Discontinued Product
0740 has been discontinued.
说明： Selective non-peptide δ antagonist
化学名： 17-(Cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Naltrindole hydrochloride
Highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ and κ opioid receptors.
许可信息
Sold with the permission of the University of Minnesota.
技术数据 for Naltrindole hydrochloride
| 分子量 | 450.96 |
| 公式 | C26H26N2O3.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 111469-81-9 |
| PubChem ID | 16760573 |
| InChI Key | KNJKRQXCFJCQHC-XXCZMEBESA-N |
| Smiles | O[C@@]24[C@]3([C@@H]7C(N6)=C(C5=C6C=CC=C5)C4)C1=C(O7)C(O)=CC=C1CC2N(CC8CC8)CC3.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Naltrindole hydrochloride
参考文献 for Naltrindole hydrochloride
参考文献是支持产品生物活性的出版物。
Ossipov et al (1994) Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat. Neurosci. Lett. 181 9 PMID: 7898778
Portoghese et al (1990) Design of peptidomimetic δ opioid receptor antagonists using the message-address concept. J.Med.Chem. 33 1714 PMID: 2160538
Shippenberg and Heidbreder (1995) The δ-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine. Eur.J.Pharmacol. 280 55 PMID: 7498254
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关键词: Naltrindole hydrochloride, Naltrindole hydrochloride supplier, δ-opioid, delta-opioid, selective, non-peptide, antagonists, DOP, Receptors, OP1, Delta, Opioid, 0740, Tocris Bioscience
24 篇 Naltrindole hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Naltrindole hydrochloride 的部分引用包括：
Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. Am J Physiol Heart Circ Physiol 38 1296 PMID: 23348063
Leal et al (2013) Peripheral δ-opioid receptors attenuate the exercise pressor reflex. Br J Pharmacol 305 H1246 PMID: 23934854
Schmid et al (2017) Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell 171 1165 PMID: 29149605
Cheng et al (2009) Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats. Neuropsychopharmacology 2011 159209 PMID: 19729491
Morse et al (2011) Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS One 6 e25643 PMID: 22003401
Neumann et al (2015) The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3. J Invest Dermatol 135 471 PMID: 25178105
Nasrallah et al (2019) Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2. Cell Rep 27 86 PMID: 30943417
Bigliardi et al (2015) Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration. PLoS One 172 501 PMID: 24628261
Chen et al (2015) Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. J Neurosci 10 e0145556 PMID: 26700862
Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. J Biomed Sci 172 642 PMID: 24827408
Yi et al (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. Diabetes 22 49 PMID: 26150021
van Cleef et al (2013) Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. Antiviral Res. 99 165 PMID: 23735301
Choi et al (2010) Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor. Korean J Pain 23 236 PMID: 21217886
Gross et al (2010) Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. Am J Physiol Heart Circ Physiol 298 H2201 PMID: 20400686
Wang et al (2010) Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A 107 13117 PMID: 20615975
Xu et al (2016) Cytoprotection against Hypoxic and/or MPP? Injury: Effect of δ-Opioid Receptor Activation on Caspase 3. Int J Mol Sci 17 PMID: 27517901
Morse et al (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol 14 17 PMID: 23497702
Smith et al (2016) Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice. Proc Natl Acad Sci U S A 113 13893 PMID: 27849613
Laurent et al (2014) δ-opioid and DArgic processes in accumbens shell modulate the cholinergic control of predictive learning and choice. J Neurosci 34 1358 PMID: 24453326
Burbassi et al (2010) Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur J Neurosci 32 1278 PMID: 20880358
Sánchez-Blázquez et al (2010) Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS One 5 e11278 PMID: 20585660
Dai et al (2018) Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner. Exp Mol Med 50 148 PMID: 30429454
Beaudry et al (2011) Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli. Neuropsychopharmacology 31 13068 PMID: 21917790
García-Fuster et al (2007) Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. Br J Pharmacol 32 399 PMID: 16482086
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