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Submit ReviewNAN-190 hydrobromide
说明： 5-HT1A antagonist
化学名： 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide
纯度： ≥98% (HPLC)
生物活性 for NAN-190 hydrobromide
NAN-190 hydrobromide is a 5-HT1A antagonist.
技术数据 for NAN-190 hydrobromide
| 分子量 | 474.4 |
| 公式 | C23H27N3O3.HBr |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 115338-32-4 |
| PubChem ID | 107966 |
| InChI Key | AXRUEPFPTQYHQD-UHFFFAOYSA-N |
| Smiles | Br.COC1=C(C=CC=C1)N1CCN(CCCCN2C(=O)C3=CC=CC=C3C2=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NAN-190 hydrobromide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 4.74 | 10 |
制备储备液 for NAN-190 hydrobromide
以下数据基于产品分子量 474.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.08 mL | 105.4 mL | 210.79 mL |
| 0.5 mM | 4.22 mL | 21.08 mL | 42.16 mL |
| 1 mM | 2.11 mL | 10.54 mL | 21.08 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
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产品说明书 for NAN-190 hydrobromide
参考文献 for NAN-190 hydrobromide
参考文献是支持产品生物活性的出版物。
Douris (1992) Effects of the putative 5-HT1A receptor antagonist NAN-190 on free feeding and on feeding induced by the 5-HT1A receptor agonist 8-OH-DPAT in the rat. Eur.J.Pharmacol. 219 105 PMID: 1397037
Glennon et al (1988) Arylpiperazine derivatives as high affinity 5-HT1A serotonin ligands. J.Med.Chem. 31 1968 PMID: 3172131
Williams and Glennon (1988) NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur.J.Pharmacol. 154 339 PMID: 2976673
If you know of a relevant reference for NAN-190 hydrobromide, please let us know.
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关键词: NAN-190 hydrobromide, NAN-190 hydrobromide supplier, 5-HT1A, antagonists, Serotonin, Receptors, 5-HT1, NAN190, 0553, Tocris Bioscience
3 篇 NAN-190 hydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NAN-190 hydrobromide 的部分引用包括：
Pagano et al (2008) Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways. Physiol Behav 20 1190 PMID: 18407463
Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282
Demarque and (2010) Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior. Neuron 67 321 PMID: 20670838
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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