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Narciclasine

Cat. No. 3715 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression
化学名： (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Narciclasine

Narciclasine is an exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro. Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.

技术数据 for Narciclasine

分子量 307.26
公式 C14H13NO7
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 29477-83-6
PubChem ID 72376
InChI Key LZAZURSABQIKGB-AEKGRLRDSA-N
Smiles OC1=C(C(N[C@]4([H])C3=C[C@H](O)[C@@H](O)[C@H]4O)=O)C3=CC2=C1OCO2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Narciclasine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.73 100

制备储备液 for Narciclasine

以下数据基于产品分子量 307.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.55 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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产品说明书 for Narciclasine

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Narciclasine

参考文献是支持产品生物活性的出版物。

Dumont et al (2007) The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia 9 766 PMID: 17898872

Ingrassia et al (2009) Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents. J.Med.Chem. 52 1100 PMID: 19199649

Lefranc et al (2009) Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol.Cancer Ther. 8 1739 PMID: 19531573

If you know of a relevant reference for Narciclasine, please let us know.

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关键词: Narciclasine, Narciclasine supplier, Narciclasine, small, g, proteins, rhoA, rho, kinases, ROCK, signaling, signalling, modulators, anticancer, antiproliferative, agents, cell, cycle, inhibitors, inhibits, actin, Cell, Cycle, Inhibitors, Actin, Apoptosis, Inducers, Rho, 3715, Tocris Bioscience

1 篇 Narciclasine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Narciclasine 的部分引用包括：

Duman et al (2019) The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest. Elife 8 PMID: 31461398

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