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Submit ReviewNBD 556
说明： Blocks HIV-1 viral cell entry; CD4 mimetic
化学名： N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)ethanediamide
纯度： ≥98% (HPLC)
生物活性 for NBD 556
NBD 556 is a CD4 mimetic (IC50 values are in low micromolar range, dependent on cell type and HIV strain). Recognizes and induces structural changes in HIV-1 envelope protein gp120, analogous to CD4 binding. Inhibits HIV-1 cell entry in CXCR4 and CCR5 expressing cell lines, by blocking virus-cell and cell-cell fusion.
技术数据 for NBD 556
| 分子量 | 337.84 |
| 公式 | C17H24ClN3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 333353-44-9 |
| PubChem ID | 1570601 |
| InChI Key | ZKXLQCIOURANAD-UHFFFAOYSA-N |
| Smiles | CC1(CC(NC(C(NC2=CC=C(C=C2)Cl)=O)=O)CC(C)(N1)C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NBD 556
参考文献 for NBD 556
参考文献是支持产品生物活性的出版物。
Zhao et al (2005) Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology 339 213 PMID: 15996703
Kwon et al (2012) Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.U.S.A. 109 5663 PMID: 22451932
Dogo-Isonagie et al (2012) Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. J.Biol.Chem. 287 15076 PMID: 22403408
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关键词: NBD 556, NBD 556 supplier, NBD556, CD4, mimetic, HIV, entry, blockers, gp120, envelope, proteins, 5811, Tocris Bioscience
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