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Submit ReviewNBOH-2C-CN hydrochloride
说明： High affinity and selective 5-HT2A agonist
别名： 25CN-NBOH
化学名： 4-[2-[[(2-Hydroxyphenyl)methyl]amino]ethyl]-2,5-dimethoxybenzonitrile hydrochloride
纯度： ≥98% (HPLC)
生物活性 for NBOH-2C-CN hydrochloride
NBOH-2C-CN hydrochloride is a high affinity, selective 5-HT2A agonist (Ki = 1.3 nM). Exhibits 100-fold selectivity for 5-HT2A over 5-HT2C. Elicits head twitch behavior in mice.
技术数据 for NBOH-2C-CN hydrochloride
| 分子量 | 348.82 |
| 公式 | C18H20N2O3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1539266-32-4 |
| PubChem ID | 90489019 |
| InChI Key | JQVAEIIIMVMJBO-UHFFFAOYSA-N |
| Smiles | OC(C=CC=C2)=C2CNCCC1=C(OC)C=C(C#N)C(OC)=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NBOH-2C-CN hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 3.49 | 10 温和加热 | |
| DMSO | 34.88 | 100 |
制备储备液 for NBOH-2C-CN hydrochloride
以下数据基于产品分子量 348.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.33 mL | 28.67 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.73 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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产品说明书 for NBOH-2C-CN hydrochloride
参考文献 for NBOH-2C-CN hydrochloride
参考文献是支持产品生物活性的出版物。
Hansen et al (2014) Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS.Chem.Neurosci. 5 243 PMID: 24397362
Fantegrossi et al (2014) Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice. Psychopharmacology (Berl.) 232 1039 PMID: 25224567
Jensen et al (2017) Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist. J.Pharmacol.Exp.Ther 361 441 PMID: 28360333
Jensen et al (2020) The selective 5-HT2A receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [ 3H]25CN-NBOH. Biochem.Pharmacol. 177 113979 PMID: 32298690
If you know of a relevant reference for NBOH-2C-CN hydrochloride, please let us know.
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关键词: NBOH-2C-CN hydrochloride, NBOH-2C-CN hydrochloride supplier, serotonin, potent, selective, high, affinity, 5-ht, 5-ht2a, agonists, receptors, hallucinogen-like, 25CN-NBOH, 5-HT2A, Receptors, 5171, Tocris Bioscience
2 篇 NBOH-2C-CN hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NBOH-2C-CN hydrochloride 的部分引用包括：
Hongyan et al (2022) Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord. Curr Biol 32 1038-1048.e2 PMID: 35104440
Wieland B et al (2020) Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex. Neuron 108 1113-1129.e6 PMID: 33080227
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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