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Submit ReviewNBQX disodium salt
说明： Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)
化学名： 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
纯度： ≥98% (HPLC)
生物活性 for NBQX disodium salt
NBQX disodium salt is a selective and competitive AMPA and kainate receptor antagonist (IC50 = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.
NBQX disodium salt is a more water-soluble form of NBQX (Cat. No. 0373).
许可信息
Sold with the permission of Novo Nordisk A/S
技术数据 for NBQX disodium salt
| 分子量 | 380.24 |
| 公式 | C12H6N4O6SNa2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 479347-86-9 |
| PubChem ID | 3272523 |
| InChI Key | SVJKYIUJRJEABK-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].NS(=O)(=O)C1=C2C(=CC=C1)C1=NC([O-])=C([O-])N=C1C=C2[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NBQX disodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 38.02 | 100 |
制备储备液 for NBQX disodium salt
以下数据基于产品分子量 380.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.15 mL | 26.3 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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产品说明书 for NBQX disodium salt
参考文献 for NBQX disodium salt
参考文献是支持产品生物活性的出版物。
Gill et al (1992) The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 580 35 PMID: 1504814
Namba et al (1994) Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 638 36 PMID: 8199874
Sheardown et al (1993) The pharmacology of AMPA receptors and their antagonists. Stroke 24 146 PMID: 7504337
Zeman and Lodg (1992) Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 106 367 PMID: 1382781
Yoon et al (2005) Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test J.Korean Med.Sci. 20 307 PMID: 15832006
If you know of a relevant reference for NBQX disodium salt, please let us know.
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关键词: NBQX disodium salt, NBQX disodium salt supplier, water, soluble, NBQX, Glutamate, AMPA, Receptors, iGlu, Ionotropic, antagonists, 1044, Tocris Bioscience
42 篇 NBQX disodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NBQX disodium salt 的部分引用包括：
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Suppression of AMPA receptors.
By
Anonymous on 06/21/2023
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Cerebellum
NBQX disodium salt was used as a control to demonstrate pharmacological isolation of AMPAR-generated whole-cell electrophysiological response. Top trace: response to rapidly applied AMPA. Bottom trace: response to AMPA+NBQX.
Needs sonication for dilution
The best option to block AMPA receptors.
By
Luiz Alexandre Magno on 06/20/2018
分析类型： In Vivo
种属： Mouse
I infused the NBQX disodium salt (22 mM) into mouse brain to block AMPA receptors in the striatum. This was done by using an internal infusion cannula. The disodium salt is the best choice for this kind of experiment because it is soluble in aqueous solutions such as NaCl 0.9%. NBQX is more specific and potent than DNQX.
Always make fresh solutions
Excellent AMPA receptor antagonist.
By
Andy Gao on 01/13/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Hippocampus
Used in extracellular bath solution during electrophysiology of hippocampal neuron culture to block glutamatergic AMPA receptors to isolate NMDA receptor currents.
Aliquot properly in dMSO
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