NDT 30805

Pricing Availability   Qty
说明: Potent NLRP3 inflammasome inhibitor
化学名: 2-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino)-5-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-thione
纯度: ≥95% (HPLC)
说明书
引用文献
评论

生物活性 for NDT 30805

NDT 30805 is a potent NLRP3 inflammasome inhibitor. Inhibits IL-1β release in peripheral blood mononuclear cell assay, ASC speck assay and in whole blood (IC50 values are 13 nM, 34 nM and 1500 nM). Inhibits Nigericin (Cat. No. 4312) and ATP-induced IL-1β release. Soluble and uncharged at physiological pH.

技术数据 for NDT 30805

分子量 414.53
公式 C23H22N6S
储存 Store at -20°C
纯度 ≥95% (HPLC)
PubChem ID 164946940
InChI Key BHTLYBBOAZYXBF-UHFFFAOYSA-N
Smiles S=C(C=C(CC1=NC=CC=C1)N2)N(C2=N3)N=C3NC4=C5C(CCC5)=CC6=C4CCC6

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NDT 30805

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.45 100

制备储备液 for NDT 30805

以下数据基于产品分子量 414.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.06 mL 24.12 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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参考文献 for NDT 30805

参考文献是支持产品生物活性的出版物。

Harrison et al (2022) Discovery and optimization of triazolopyrimidinone derivatives as selective NLRP3 inflammasome inhibitors. ACS Med.Chem.Lett. 13 1321 PMID: 35978696


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关键词: NDT 30805, NDT 30805 supplier, NDT30805, potent, selective, nlrp3, inflammasome, inhibitor, inhibitors, inhibit, inhibits, interlukin, 1, beta, IL1b, Inflammasomes, 7808, Tocris Bioscience

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