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Submit ReviewNDT 30805 is a potent NLRP3 inflammasome inhibitor. Inhibits IL-1β release in peripheral blood mononuclear cell assay, ASC speck assay and in whole blood (IC50 values are 13 nM, 34 nM and 1500 nM). Inhibits Nigericin (Cat. No. 4312) and ATP-induced IL-1β release. Soluble and uncharged at physiological pH.
分子量 | 414.53 |
公式 | C23H22N6S |
储存 | Store at -20°C |
纯度 | ≥95% (HPLC) |
PubChem ID | 164946940 |
InChI Key | BHTLYBBOAZYXBF-UHFFFAOYSA-N |
Smiles | S=C(C=C(CC1=NC=CC=C1)N2)N(C2=N3)N=C3NC4=C5C(CCC5)=CC6=C4CCC6 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 41.45 | 100 |
以下数据基于产品分子量 414.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.41 mL | 12.06 mL | 24.12 mL |
5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
参考文献是支持产品生物活性的出版物。
Harrison et al (2022) Discovery and optimization of triazolopyrimidinone derivatives as selective NLRP3 inflammasome inhibitors. ACS Med.Chem.Lett. 13 1321 PMID: 35978696
If you know of a relevant reference for NDT 30805, please let us know.
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