Necrosulfonamide

Name: Necrosulfonamide
Brand: Tocris Bioscience
SKU: 5025
Rating: 5 (1 reviews)

Cat. No. 5025 19 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Necroptosis inhibitor; also inhibits pyroptosis

化学名： (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

纯度： ≥98% (HPLC)

说明书

引用文献 (19)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Necrosulfonamide

Necrosulfonamide is a necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.

技术数据 for Necrosulfonamide

分子量	461.47
公式	C₁₈H₁₅N₅O₆S₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1360614-48-7
PubChem ID	1566236
InChI Key	FNPPHVLYVGMZMZ-XBXARRHUSA-N
Smiles	O=C(NC2=CC=C(S(NC3=C(OC)N=CC=N3)(=O)=O)C=C2)/C=C/C1=CC=C([N+]([O-])=O)S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Necrosulfonamide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	9.23	20

制备储备液 for Necrosulfonamide

以下数据基于产品分子量 461.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	10.83 mL	54.17 mL	108.35 mL
1 mM	2.17 mL	10.83 mL	21.67 mL
2 mM	1.08 mL	5.42 mL	10.83 mL
10 mM	0.22 mL	1.08 mL	2.17 mL

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产品说明书 for Necrosulfonamide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Necrosulfonamide

参考文献是支持产品生物活性的出版物。

Zhou et al (2012) New components of the necroptotic pathway. Protein Cell 3 811 PMID: 23073834

Sun et al (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148 213 PMID: 22265413

Kreuzaler et al (2012) Killing a cancer: what are the alternatives? Nat.Rev.Cancer. 12 411 PMID: 22576162

Pandeya et al (2019) Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm 10 660 PMID: 31191857

If you know of a relevant reference for Necrosulfonamide, please let us know.

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关键词: Necrosulfonamide, Necrosulfonamide supplier, non-apoptotic, cell, death, necroptosis, necrosis, necrosome, mixed, lineage, kinase, domain-like, protein, MLKL, receptor, interacting, serine, threonine, kinases, 3, RIP3, Gasdermin, D, GSDMD, pyroptosis, inhibitors, inhibits, Necroptosis, Inflammasomes, 5025, Tocris Bioscience

19 篇 Necrosulfonamide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Necrosulfonamide 的部分引用包括：

Bittner et al (2016) Death receptor 3 mediates necroptotic cell death. Cellular and Molecular Life Sciences PMID: 27592300

Junying et al (2021) RIPK1 Promotes Energy Sensing by the mTORC1 Pathway. Mol Cell 81 370-385.e7 PMID: 33271062

Ferenc et al (2021) Caspase-9 acts as a regulator of necroptotic cell death. FEBS J 288 6476-6491 PMID: 33899329

Michael E et al (2021) Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection. Elife 10 PMID: 34871166

Heulot et al (2016) The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner. Oncotarget 7 64342 PMID: 27602963

Svetlana et al (2022) A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling. Cell 185 2354-2369.e17 PMID: 35568036

Gonzalez-Juarbe et al (2017) Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ 24 917 PMID: 28387756

Xie et al (2017) The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Rep 20 1692 PMID: 28813679

Charles E et al (2019) Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells. Biochim Biophys Acta Mol Cell Biol Lipids 1864 158-167 PMID: 30472325

Kevin S et al (2020) Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis. Cell Rep 32 108062 PMID: 32846120

Tanya A et al (2020) Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis. Viruses 12 PMID: 32854254

Kyung-Min et al (2020) Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer. Breast Cancer Res 22 130 PMID: 33239070

James et al (2020) Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc Natl Acad Sci U S A 117 33272-33281 PMID: 33318170

Simon et al (2023) PRMT5-mediated regulatory arginine methylation of RIPK3. Cell Death Discov 9 14 PMID: 36658119

Yuan et al (2023) Necroptotic kinases are involved in the reduction of depression-induced astrocytes and fluoxetine's inhibitory effects on necroptotic kinases. Front Pharmacol 13 1060954 PMID: 36686688

Gonzalez-Juarbe et al (2015) Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. Channels (Austin) 11 e1005337 PMID: 26659062

Greer et al (2018) ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget 9 18454 PMID: 29719618

Chefetz et al (2019) A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep 26 3061 PMID: 30865894

Bagnjuk et al (2019) Necroptosis in primate luteolysis: a role for ceramide. Cell Death Discov 5 67 PMID: 30774995

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Necrosulfonamide work well to block pyroptosis.

By Xiaogang Wang on 06/12/2020

分析类型： In Vitro

种属： Human

细胞系/组织： THP-1 cell line

We used Necrosulfonamide as a positive control to inhibit the induction of pyroptosis by staphylococcal cytolysin. Differentiated THP-1 cells were pretreated with 25uM Necrosulfonamide (NSA) for 1 h before treating with or without 1 ug/ml Staphylococcal pore-forming toxin for 4 h. The LDH release in culture supernatants of treated cells was measured. Our data indicated that Necrosulfonamide treatment can significantly inhibit staphylococcal cytolysin induced pyroptosis.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Necrosulfonamide

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.