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Nefiracetam

Cat. No. 2851 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cognitive enhancer
别名： DM 9384
化学名： N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
纯度： ≥99% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Nefiracetam

Nefiracetam is a cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo.

技术数据 for Nefiracetam

分子量 246.3
公式 C14H18N2O2
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 77191-36-7
PubChem ID 71157
InChI Key NGHTXZCKLWZPGK-UHFFFAOYSA-N
Smiles O=C(NC2=C(C)C=CC=C2C)CN1C(CCC1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nefiracetam

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.63 100
ethanol 24.63 100

制备储备液 for Nefiracetam

以下数据基于产品分子量 246.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.3 mL 40.6 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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参考文献 for Nefiracetam

参考文献是支持产品生物活性的出版物。

Narahashi et al (2004) Mechanisms of action of cognitive enhancers on neuroreceptors. Biol.Pharm.Bull. 27 1701 PMID: 15516710

Ueda et al (2004) The cognitive-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. J.Pharmacol.Exp.Ther. 309 200 PMID: 14718588

Kitano et al (2005) Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Epilepsia 46 1561 PMID: 16190926

If you know of a relevant reference for Nefiracetam, please let us know.

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关键词: Nefiracetam, Nefiracetam supplier, Cognitive, enhancer, activates, L/N-type, Ca2+, channels, potentiates, NMDA, currents, Muscarinic, Receptors, Acetylcholine, Nicotinic, nAChR, Calcium, CaV, Channels, L-Type, N-Type, voltage-gated, voltage-dependent, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, DM9384, DM, 9384, Other, Cav1.x, Non-selective, Muscarinics, Cav2.x, 2851, Tocris Bioscience

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该领域的文献

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Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.