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Submit ReviewNF 110
说明： Potent P2X3 antagonist
化学名： 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonic acid tetrasodium salt
纯度： ≥90% (HPLC)
生物活性 for NF 110
NF 110 is a high affinity P2X3 receptor antagonist (Ki values are 36, 82 and 4144 nM for P2X3, P2X1 and P2X2 recombinant receptors respectively). Shows no activity at P2Y1, P2Y2 and P2Y11 receptors (IC50 > 10 μM). Potently inhibits α,β-meATP-evoked desensitizing currents in rat DRG neurons (IC50 = 527 nM). Shows antitumor activity against several tumor types. Also inhibits DNA-binding activity of HMGA2 (IC50 = 0.87 μM).
This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
技术数据 for NF 110
| 分子量 | 1096.9 |
| 公式 | C41H28N6Na4O17S4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥90% (HPLC) |
| CAS Number | 111150-22-2 |
| PubChem ID | 16066783 |
| InChI Key | AQJHZNCSXLBXMY-UHFFFAOYSA-J |
| Smiles | [Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC=C(NC(=O)C2=CC(=CC(NC(=O)NC3=CC(=CC(=C3)C(=O)NC3=CC=C(C=C3)S([O-])(=O)=O)C(=O)NC3=CC=C(C=C3)S([O-])(=O)=O)=C2)C(=O)NC2=CC=C(C=C2)S([O-])(=O)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NF 110
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 40 | 37 |
制备储备液 for NF 110
以下数据基于产品分子量 1096.9。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.37 mM | 2.46 mL | 12.32 mL | 24.64 mL |
| 1.85 mM | 0.49 mL | 2.46 mL | 4.93 mL |
| 3.7 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 18.5 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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产品说明书 for NF 110
参考文献 for NF 110
参考文献是支持产品生物活性的出版物。
Dhar et al (2000) Antitumour activity of suramin analogues in human tumour cell lines and primary cultures of tumour cells from patients. Eur.J.Cancer 36 803 PMID: 10762755
Kassack et al (2004) Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist. Eur.J.Med.Chem. 39 345 PMID: 15072843
Hausmann et al (2006) The suramin analog 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic Mol.Pharmacol. 69 2058 PMID: 16551782
Su et al (2020) Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci.Rep. 10 18850 PMID: 33139812
If you know of a relevant reference for NF 110, please let us know.
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关键词: NF 110, NF 110 supplier, Potent, P2X3, antagonists, Receptors, Purinergic, purinoceptors, NF110, HMGA2, inhibitors, inhibits, high, mobility, group, protein, AT-hook, 2, DNA, binding, P2X, 2548, Tocris Bioscience
4 篇 NF 110 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NF 110 的部分引用包括：
Nishimura et al (2015) The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog 11 e1005184 PMID: 26430888
Su et al (2020) Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci Rep 10 18850 PMID: 33139812
Dosch et al (2019) Connexin-43-dependent ATP release mediates macrophage activation during sepsis. Elife 8 PMID: 30735126
Chandra et al (2019) Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus. Viruses 11 PMID: 30870979
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.