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说明： Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant
化学名： (3R,4S)-rel-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H)-1,2,4-triazol-1-carbonyl)-4-piperidinyl]-2-azetidinone
纯度： ≥98% (HPLC)
生物活性 for NF 1819
NF 1819 is a potent and selective irreversible MAGL inhibitor (IC50 values are 0.25 and 7.4 nM at rMAGL and hMAGL, respectively). Exhibits 389-fold selectivity over hFAAH and exhibits minimal binding at CB receptors (IC50 > 10 μM). Alleviates symptoms in a MS in vivo model. Exhibits analgesic effects in an acute inflammatory pain model in vivo. Ameliorates neuropathic hypersensitivity induced by oxaliplatin (Cat. No. 2623). Displays high membrane permeability and brain penetrant.
技术数据 for NF 1819
| 分子量 | 463.46 |
| 公式 | C24H22FN5O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1881244-28-5 |
| PubChem ID | 127032456 |
| InChI Key | XRIROGBLGLPXQI-FGZHOGPDSA-N |
| Smiles | FC1=CC=C([C@@H]2[C@@H](C3=CC=C4OCOC4=C3)N(C2=O)C5CCN(C(N6C=NC=N6)=O)CC5)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NF 1819
参考文献 for NF 1819
参考文献是支持产品生物活性的出版物。
Brindisi et al (20106) Development and pharmacological characterization of selective blockers of 2-arachidonoyl glycerol degradation with efficacy in rodent models of multiple sclerosis and pain. J.Med.Chem. 59 2612 PMID: 26888301
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关键词: NF 1819, NF 1819 supplier, NF1819, Potent, selective, irreversible, MAGL, inhibitors, inhibits, MS, multiple, sclerosis, analgesics, neuropathic, hypersensitivity, membrane, permeable, brain, penetrant, 5956, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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