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Submit ReviewNF 279
说明： Potent and selective P2X1 antagonist
化学名： 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
纯度： ≥95% (HPLC)
生物活性 for NF 279
NF 279 is a a potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases.
This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
技术数据 for NF 279
| 分子量 | 1401.1 |
| 公式 | C49H30N6Na6O23S6 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 202983-32-2 |
| PubChem ID | 4467 |
| InChI Key | RJMCMLNRWDKUDB-UHFFFAOYSA-H |
| Smiles | [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)C1=CC2=C(C(NC(=O)C3=CC=C(NC(=O)C4=CC=C(NC(=O)NC5=CC=C(C=C5)C(=O)NC5=CC=C(C=C5)C(=O)NC5=C6C(C=C(C=C6S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C5)S([O-])(=O)=O)C=C4)C=C3)=CC=C2S([O-])(=O)=O)C(=C1)S([O-])(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NF 279
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 25 | 18 |
制备储备液 for NF 279
以下数据基于产品分子量 1401.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.18 mM | 3.97 mL | 19.83 mL | 39.65 mL |
| 0.9 mM | 0.79 mL | 3.97 mL | 7.93 mL |
| 1.8 mM | 0.4 mL | 1.98 mL | 3.97 mL |
| 9 mM | 0.08 mL | 0.4 mL | 0.79 mL |
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产品说明书 for NF 279
参考文献 for NF 279
参考文献是支持产品生物活性的出版物。
Damer et al (1998) NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. Eur.J.Pharmacol. 350 R5 PMID: 9683026
Klapperstuck et al (2000) Antagonism by the suramin analogue NF 279 on human P2X1 and P2X7 receptors. Eur.J.Pharmacol. 387 245 PMID: 10650169
Rettinger et al (2000) The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor. Neuropharmacology 39 2044 PMID: 10963748
If you know of a relevant reference for NF 279, please let us know.
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关键词: NF 279, NF 279 supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, NF279, P2X, 1199, Tocris Bioscience
9 篇 NF 279 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NF 279 的部分引用包括：
Nishimura et al (2015) The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog 11 e1005184 PMID: 26430888
Aliagas et al (2014) High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors. PLoS One 2014 509027 PMID: 24707115
Aliagas et al (2013) Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the "adenosine hypothesis". Purinergic Signal 9 599 PMID: 23771238
Donnelly-Roberts et al (2009) Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors. Br J Pharmacol 157 1203 PMID: 19558545
Ibáñez et al (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen 15 359 PMID: 22256970
Hazleton et al (2012) Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol 188 4488 PMID: 22450808
Inscho et al (2003) Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest 112 1895 PMID: 14679185
Kennedy et al (2007) Identification of atropine- and P2X1 receptor antagonist-resistant, neurogenic contractions of the urinary bladder. J Neurosci 27 845 PMID: 17251425
Luke and Hexum (2008) UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation. Mediators Inflamm 4 323 PMID: 18777108
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.