主页 / 药理学 / Transporters / Neurotransmitter Transporters / Glycine Transporters / Glycine Transporter Inhibitors / NFPS

NFPS

Cat. No. 2789 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective non-transportable GlyT1 inhibitor
别名： (±)-NFPS
化学名： N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NFPS

NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.

R-enantiomer also available.

技术数据 for NFPS

分子量 393.45
公式 C24H24FNO3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 405225-21-0
PubChem ID 5311283
InChI Key FDORQEIHOKEJNX-UHFFFAOYSA-N
Smiles FC1=CC=C(C(OC2=CC=C(C3=CC=CC=C3)C=C2)CCN(C)CC(O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NFPS

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 3.93 10
ethanol 1.97 5 温和加热

制备储备液 for NFPS

以下数据基于产品分子量 393.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 25.42 mL 127.08 mL 254.16 mL
0.5 mM 5.08 mL 25.42 mL 50.83 mL
1 mM 2.54 mL 12.71 mL 25.42 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for NFPS

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for NFPS

参考文献是支持产品生物活性的出版物。

Bergeron et al (1998) Modulation of N-MthD.-aspartate receptor function by glycine transport. Proc.Natl.Acad.Sci.USA 95 15730

Harsing Jr. et al (2003) The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study. Pharmacol.Biochem.Behav. 74 881

Mallorga et al (2003) Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology 45 585 PMID: 12941372

If you know of a relevant reference for NFPS, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Glycine Transporter Inhibitors

关键词: NFPS, NFPS supplier, Selective, non-transportable, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, (+/-)-NFPS, 2789, Tocris Bioscience

2 篇 NFPS 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NFPS 的部分引用包括：

DeBrouse et al (2013) Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site. Alcohol Clin Exp Res 37 223 PMID: 22934986

Romei et al (2016) Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission. Brain Research Bulletin 127 100 PMID: 27565422

您是否知道使用了 Tocris NFPS 的优秀论文？ 请告知我们.

NFPS 的评论

目前没有该产品的评论。 Be the first to review NFPS and earn rewards!

Have you used NFPS?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review