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Nilutamide

Cat. No. 1759 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1759 has been discontinued.

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说明： Androgen receptor antagonist. Orally active
别名： RU 23908
化学名： 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
纯度： ≥99% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Nilutamide

Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active.

技术数据 for Nilutamide

分子量 317.22
公式 C12H10F3N3O4
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 63612-50-0
PubChem ID 4493
InChI Key XWXYUMMDTVBTOU-UHFFFAOYSA-N
Smiles CC1(C)NC(=O)N(C1=O)C1=CC=C(C(=C1)C(F)(F)F)N(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Nilutamide

参考文献是支持产品生物活性的出版物。

Ayub and Levell (1987) Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. J.Steroid Biochem. 28 43 PMID: 2956461

Raynaud et al (1979) Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues. J.Steroid Biochem. 11 93 PMID: 385986

Raynaud et al (1984) The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer. The Prostate 5 299 PMID: 6374639

Raynaud et al (1985) Pharmacology and clinical studies with RU 23908 (Anandron). Prog.Clin.Biol.Res. 185A 99 PMID: 4034583

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关键词: Nilutamide, Nilutamide supplier, Androgen, receptor, antagonists, Orally, active, Dihydrotestosterone, Receptors, RU23908, chemotherapeutics, RU, 23908, Receptor, 1759, Tocris Bioscience

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