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NITD 008

Cat. No. 6045 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Antiflaviviral; active against Zika, Dengue and Hepatitis C viruses
化学名： 7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
纯度： ≥97% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NITD 008

NITD 008 is a selective flavivirus inhibitor. Adenosine analog. Inhibits dengue virus (EC50 = 0.64 μM), hepatitis C virus and cellular entry of Zika virus. Reduces increases of cytokines and NS1 and prevents death in dengue-infected mice. Active in vivo. Orally bioavailable.

技术数据 for NITD 008

分子量 290.27
公式 C13H14N4O4
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 1044589-82-3
PubChem ID 44633776
InChI Key NKRAIOQPSBRMOV-NRMKKVEVSA-N
Smiles NC1=C2C=CN(C2=NC=N1)[C@@H]3O[C@@H]([C@H]([C@@]3(C#C)O)O)CO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NITD 008

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.81 20

制备储备液 for NITD 008

以下数据基于产品分子量 290.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 17.23 mL 86.13 mL 172.25 mL
1 mM 3.45 mL 17.23 mL 34.45 mL
2 mM 1.72 mL 8.61 mL 17.23 mL
10 mM 0.34 mL 1.72 mL 3.45 mL

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参考文献 for NITD 008

参考文献是支持产品生物活性的出版物。

Yin et al (2009) An adenosine nucleoside inhibitor of dengue virus. Proc.Natl.Acad.Sci.USA. 106 20435 PMID: 19918064

Barrows et al (2016) A screen of FDA-approved drugs for inhibitors of Zika virus infection. Cell.Host.Microbe. 20 259 PMID: 27476412

If you know of a relevant reference for NITD 008, please let us know.

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关键词: NITD008, NITD008 supplier, NITD008, antiviral, selective, flavivirus, inhibitors, inhibits, dengue, hepatitis, C, Zika, virus, active, in, vivo, orally, bioavailable, Flaviviruses, Hepatitis, Viruses, 6045, Tocris Bioscience

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