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Submit ReviewNNC 05-2090 hydrochloride
说明： GABA uptake inhibitor; moderately BGT-1 selective
化学名： 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride
纯度： ≥98% (HPLC)
生物活性 for NNC 05-2090 hydrochloride
NNC 05-2090 hydrochloride is a GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively).
技术数据 for NNC 05-2090 hydrochloride
| 分子量 | 451.01 |
| 公式 | C27H30N2O2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 184845-18-9 |
| PubChem ID | 18782760 |
| InChI Key | WDFXPKKFSNMGOO-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(C=CC=C1)C1(O)CCN(CCCN2C3=C(C=CC=C3)C3=C2C=CC=C3)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NNC 05-2090 hydrochloride
参考文献 for NNC 05-2090 hydrochloride
参考文献是支持产品生物活性的出版物。
Thomsen et al (1997) 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br.J.Pharmacol. 120 983 PMID: 9134205
Dalby et al (1997) Anticonvulsive properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 28 51 PMID: 9255599
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关键词: NNC 05-2090 hydrochloride, NNC 05-2090 hydrochloride supplier, GABA, reuptake, inhibitors, inhibits, moderately, BGT-1, selective, Transporters, Monoamine, Neurotransmitter, NNC052090, hydrochloride, 2747, Tocris Bioscience
1 篇 NNC 05-2090 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NNC 05-2090 hydrochloride 的部分引用包括：
Wang et al (2015) Neuronal γ-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA. Sleep 9 188 PMID: 26041994
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