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Submit ReviewNociceptin
说明： Endogenous NOP agonist
别名： Orphanin FQ
纯度： ≥95% (HPLC)
生物活性 for Nociceptin
Nociceptin is an endogenous ligand for the NOP opioid receptor (pKi = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pKi < 6).
技术数据 for Nociceptin
| 分子量 | 1809 |
| 公式 | C79H129N27O22 |
| 序列 | FGGFTGARKSARKLANQ |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 170713-75-4 |
| PubChem ID | 16131448 |
| InChI Key | PULGYDLMFSFVBL-SMFNREODSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Nociceptin
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Nociceptin
参考文献 for Nociceptin
参考文献是支持产品生物活性的出版物。
Guerrini et al (2000) Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A. Peptides 21 923 PMID: 10998526
Henderson and McKnight (1997) The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 18 293 PMID: 9277133
Reinscheid et al (1995) Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 270 792 PMID: 7481766
Meunier et al (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377 532 PMID: 7566152
If you know of a relevant reference for Nociceptin, please let us know.
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关键词: Nociceptin, Nociceptin supplier, Endogenous, NOP, agonists, Nociceptin, Receptors, ORL1, OP4, Opioid, Orphanin, FQ, 0910, Tocris Bioscience
16 篇 Nociceptin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Nociceptin 的部分引用包括：
Wang et al (2019) Nociceptin Receptor Is Overexpressed in Non-small Cell Lung Cancer and Predicts Poor Prognosis. Front Oncol 9 235 PMID: 31024840
Wang et al (2015) Bupren.-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. Psychopharmacology (Berl) 19 2587 PMID: 26153065
Kelly et al (2015) The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. Neurochem Res 232 305 PMID: 24973897
Farrag et al (2015) Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats. BMC Complement Altern Med 10 e0125566 PMID: 26017846
Kallupi et al (2014) Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology 39 1081 PMID: 24169802
Lee et al (2011) Differential pharmacological actions of meth. and Bupren. in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors. PLoS One 36 2008 PMID: 21671107
Fox and Hentges (2017) Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity. J Neurosci 37 8667 PMID: 28821664
Schmid et al (2017) Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell 171 1165 PMID: 29149605
Popiolek-Barczyk et al (2014) MinCyc enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain. Biomed Res Int 2014 762930 PMID: 25276817
Miranda-Morales et al (2013) Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats. Behav Brain Res 245 137 PMID: 23439216
McIlwrath and Westlund (2015) Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. J Cell Mol Med 21 836 PMID: 25624717
Kokkola et al (2005) S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC Cell Biol 6 21 PMID: 15850493
Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736
McLeod et al (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. World J Gastroenterol 132 1175 PMID: 11250866
Werthwein et al (1999) Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro. Br J Pharmacol 127 300 PMID: 10369486
Giuliani and Maggi (1996) Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide. Br J Pharmacol 118 1567 PMID: 8842416
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.