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Submit ReviewNocII is an orphan neuropeptide, flanking nociceptin in the precursor pronociceptin. Stimulates locomotion in mice, possibly through a novel specific receptor.
分子量 | 2081.4 |
公式 | C92H141N23O28S2 |
序列 | FSEFMRQYLVLSMQSSQ |
储存 | Desiccate at -20°C |
CAS Number | 188119-47-3 |
PubChem ID | 90479756 |
InChI Key | PPKKOTLGXBHLAB-XVHSACDVSA-N |
Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Florin et al (1997) Orphan neuropeptide NocII, a putative pronociceptin maturation product, stimulates locomotion in mice. NeuroReport 8 705 PMID: 9106751
Florin et al (1999) Comparison of behavioural effects of NocII or NocIII, two related pronociceptin-derived peptides. Life Sci. 65 2727 PMID: 10622282
关键词: NocII, NocII supplier, Orphan, neuropeptide, Nociceptin, Receptors, ORL1, OP4, NOP, Opioid, neuropeptides, 1119, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 NocII 的部分引用包括:
Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep 21 2895 PMID: 29212034
Laudenbach et al (2001) Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain. J Clin Invest 107 457 PMID: 11181645
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.