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说明： Monovalent cation ionophore
别名： Ammonium Ionophore I
化学名： (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
纯度： ≥93%
生物活性 for Nonactin
Nonactin is a monovalent cation ionophore that displays selectivity for K+ and NH4+ (K+ = NH4+ > Na+ > Mg2+ > Li+ >> Ca2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
技术数据 for Nonactin
| 分子量 | 736.94 |
| 公式 | C40H64O12 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥93% |
| CAS Number | 6833-84-7 |
| PubChem ID | 72519 |
| InChI Key | RMIXHJPMNBXMBU-QIIXEHPYSA-N |
| Smiles | [H][C@]3(CC[C@@](C[C@@H](C)OC([C@H](C)[C@@]4([H])CC[C@](C[C@H](C)OC([C@H]5C)=O)([H])O4)=O)([H])O3)[C@H](C)C(O[C@@H](C)C[C@@]1([H])O[C@]([C@@H](C)C(O[C@H](C)C[C@]2([H])O[C@@]5([H])CC2)=O)([H])CC1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Nonactin
参考文献 for Nonactin
参考文献是支持产品生物活性的出版物。
Borrel et al (1994) Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effects of ionophores on 4'O-tetrahydropyranyl-adriamycin incorporation in K562 drug-resistant cells. Eur.J.Biochem. 223 125 PMID: 7518390
Woo et al (1999) Nonactin biosynthesis: the product of nonS catalyzes the formation of the furan ring of nonactic acid. Antimicrob.Agents Chemother. 43 1662 PMID: 10390219
Garcia et al (2003) Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane. J.Pharm.Biomed.Anal. 31 11 PMID: 12560044
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关键词: Nonactin, Nonactin supplier, Monovalent, cation, ionophores, NH4+, K+, Potassium, antibiotics, Ammonium, Ionophore, I, Ionophores, 2505, Tocris Bioscience
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