Nor NOHA monoacetate

Cat. No. 6370 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Arginase inhibitor

化学名： (2S)-2-Amino-4-[[(hydroxyamino)iminomethyl]amino]butanoic acid monoacetate

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Nor NOHA monoacetate

Nor NOHA monoacetate is a reversible, competitive arginase inhibitor (IC₅₀ = 2 μM). Exhibits 10-fold selectivity for human type II arginase over type I. Enhances the effect of acetylcholine on isolated aortic and mesenteric arterial rings. Inhibits growth of lung carcinoma implants in mice.

技术数据 for Nor NOHA monoacetate

分子量	236.23
公式	C₅H₁₂N₄O₃.C₂H₄O₂
储存	Store at -20°C
CAS Number	2250019-93-1
PubChem ID	131648256
InChI Key	RYUGHGOGNIYFKU-DFWYDOINSA-N
Smiles	N[C@@H](CCNC(NO)=N)C(O)=O.O=C(O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nor NOHA monoacetate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	23.62	100

制备储备液 for Nor NOHA monoacetate

以下数据基于产品分子量 236.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.23 mL	21.17 mL	42.33 mL
5 mM	0.85 mL	4.23 mL	8.47 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

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产品说明书 for Nor NOHA monoacetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Nor NOHA monoacetate

参考文献是支持产品生物活性的出版物。

Custot et al (1997) The new α-amino acid N^ω-hydroxy-nor-L-arginine: a high affinity inhibitor of arginase well adapted to bind to its manganese cluster. J.Am.Chem.Soc. 119 4086

Colleluori and Ash et al (2001) Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40 9356 PMID: 11478904

Huynh et al (2009) The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br.J.Pharmacol. 156 84 PMID: 19133993

Rodriguez et al (2004) Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 64 5839 PMID: 15313928

If you know of a relevant reference for Nor NOHA monoacetate, please let us know.

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关键词: Nor NOHA monoacetate, Nor NOHA monoacetate supplier, arginase, inhibitors, inhibits, reversible, competitive, 189302-40-7, Other, Hydrolases, Immune, Checkpoints, 6370, Tocris Bioscience

2 篇 Nor NOHA monoacetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Nor NOHA monoacetate 的部分引用包括：

Rogier C et al (2020) Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158. J Struct Biol X 4 100014 PMID: 32647818

Rogier C et al (2020) High-Throughput Fluorescence-Based Activity Assay for Arginase-1. SLAS Discov 25 1018-1025 PMID: 32418491

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