[Nphe¹]Nociceptin(1-13)NH₂

Name: [Nphe 1 ]Nociceptin(1-13)NH 2
Brand: Tocris Bioscience
SKU: 1308

Cat. No. 1308 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1308 has been discontinued.

View all NOP Receptors products.

说明： Selective, competitive nociceptin antagonist

说明书

引用文献 (3)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for [Nphe¹]Nociceptin(1-13)NH₂

[Nphe¹]Nociceptin(1-13)NH₂ is a selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pK_i = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.

技术数据 for [Nphe¹]Nociceptin(1-13)NH₂

分子量	1381.6
公式	C₆₁H₁₀₀N₂₂O₁₅
序列	GGGFTGARKSARK (Modifications: Gly-1 = N-Bn-Gly, Lys-13 = C-terminal amide)
储存	Desiccate at -20°C
CAS Number	267234-08-2
PubChem ID	10654047
InChI Key	NMBZIPCESQREMT-UVDGFCMYSA-N
Smiles	[H]N(CC(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for [Nphe¹]Nociceptin(1-13)NH₂

分析证书/产品说明书

化学品安全技术说明书

参考文献 for [Nphe¹]Nociceptin(1-13)NH₂

参考文献是支持产品生物活性的出版物。

Calo et al (2000) Characterization of [Nphe¹]nociceptin(1-13)NH₂, a new selective nociceptin receptor antagonist. Br.J.Pharmacol. 129 1183 PMID: 10725267

Hashimoto et al (2000) Antagonistic effects of [Nphe¹]nociceptin(1-13)NH₂ on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor. Neurosci.Lett. 278 109 PMID: 10643813

Pheng et al (2000) [Nphe¹]nociceptin-(1-13)NH₂ selectively antagonizes nociceptin effects in the rabbit isolated ileum. Eur.J.Pharmacol. 397 383 PMID: 10844138

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关键词: [NPhe1]Nociceptin(1-13)NH2, [NPhe1]Nociceptin(1-13)NH2 supplier, Selective, competitive, nociceptin, antagonists, Receptors, ORL1, OP4, NOP, Opioid, 1308, Tocris Bioscience

3 篇 [Nphe¹]Nociceptin(1-13)NH₂ 的引用文献

引用文献是使用了 Tocris 产品的出版物。 [Nphe¹]Nociceptin(1-13)NH₂ 的部分引用包括：

Schmid et al (2017) Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell 171 1165 PMID: 29149605

Kallupi et al (2014) Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology 39 1081 PMID: 24169802

Wu & Liu (2018) ORL₁ activation mediates a novel ORL₁ receptor agonist SCH221510 analgesia in neuropathic pain in rats. J Mol Neurosci 66 10 PMID: 30074175