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Submit ReviewNPS ALX Compound 4a dihydrochloride
说明： Potent and selective 5-HT6 antagonist
化学名： 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indole dihydrochloride
纯度： ≥99% (HPLC)
生物活性 for NPS ALX Compound 4a dihydrochloride
NPS ALX Compound 4a dihydrochloride is a potent and competitive 5-HT6 antagonist (IC50 = 7.2 nM, Ki = 0.2 nM) that displays selectivity over other 5-HT and D2 receptors.
技术数据 for NPS ALX Compound 4a dihydrochloride
| 分子量 | 504.47 |
| 公式 | C25H25N3O2S.2HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1781934-44-8 |
| PubChem ID | 56972226 |
| InChI Key | XQQYORJJFZQWNA-UHFFFAOYSA-N |
| Smiles | O=S(N2C1=CC(N5CCN(CCC6)C6C5)=CC=C1C=C2)(C3=C(C=CC=C4)C4=CC=C3)=O.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for NPS ALX Compound 4a dihydrochloride
参考文献 for NPS ALX Compound 4a dihydrochloride
参考文献是支持产品生物活性的出版物。
Isaac et al (2000) 6-bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg.Med.Chem.Letts. 10 1719
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关键词: NPS ALX Compound 4a dihydrochloride, NPS ALX Compound 4a dihydrochloride supplier, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, NPSALX, Compound4a, dihydrochloride, 3285, Tocris Bioscience
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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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